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Advanced Drug Delivery Systems: Methods & Applications

Explore innovative drug delivery methods such as solvent casting and double emulsion for controlled release. Learn about factors influencing microsphere properties and modulation of drug release using PEG in PLGA/PDLA discs.

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Advanced Drug Delivery Systems: Methods & Applications

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  1. Week 6 Particle Based Drug Delivery Systems References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 2, 201-214.

  2. Solvent Casting Method

  3. Solvent Casting Method

  4. PROTEIN SOLUTION POLYMER-DCM SOLUTION ADD TO PVA IN WATER & MIX SECONDARY EMULSION (W/O/W) ULTRA SONICATION SOLVENT EVAPORATION PRIMARY EMULSION (W/O) FILTRATION AND DRYING Double Emulsion Method

  5. Spray Dried Microspheres • Inlet temperature • Polymer concentration • Pump feed rate • Aspirator ratio • Compressed air flow rate • Drug loadings

  6. F.J. Wang and C.H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”, J. Controlled Release, 81 263-280 (2002). Microsphere surface morphology using different polymer solution concentrations A B D C

  7. F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002).. Degradation ofmicrospheres PLGA 65:35 1 month PLGA 50:50 1 month PDLA 3 month PLGA 85:15 3 month

  8. F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002). Modulation of release by PEG large discs (diameter =13mm, thickness = 1mm) small discs (diameter = 5mm, thickness =1mm)

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