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Chapter 19, part B

Chapter 19, part B. The Kidneys. Reabsorption: 1 0 Active Transport. (Passive diffusion in) Active Transport Na + to ECF K + into cell ATP-ase Uses energy Na + ECF  peritubular capillaries Reabsorption  blood. Reabsorption: 1 0 Active Transport.

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Chapter 19, part B

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  1. Chapter 19, part B The Kidneys

  2. Reabsorption: 10 Active Transport • (Passive diffusion in) • Active Transport • Na+ to ECF • K+ into cell • ATP-ase • Uses energy • Na+ ECF peritubular capillaries • Reabsorption  blood

  3. Reabsorption: 10 Active Transport Figure 19-11: Sodium reabsorption in the proximal tubule

  4. Reabsorption: Secondary Active Transport • Na+ linked 20 transport • Symport • Glucose • Ions • Amino acids • Proximal tubule, key site Figure 19-12: Sodium-linked glucose reabsorption in the proximal tubule

  5. Reabsorption: Passive Transport & Trancytosis • Passive Transport of urea • Na+ pumped out • H2O follows • Passive •  [urea] • [urea] higher than ECF • passive diffusion to ECF • Trancytosis of proteins

  6. Reabsorption: Passive Transport & Trancytosis Figure 19-13: Passive reabsorption of urea in the proximal tubule

  7. Reabsorption: Receptors can Limit • Transport maximum • Saturation (# of receptors) • Competition • Specificity • Renal Threshold • Example: glucosuria

  8. Reabsorption: Receptors can Limit Figure 19-15: Glucose handling by the nephron

  9. Secretion: From Peritubular Blood vessels & ECF • Active Transport into nephron tubules • Example: K+ & H+ (more on this next unit)

  10. Secretion: From Peritubular Blood vessels & ECF Figure 19-2 : Filtration, reabsorption, secretion, and excretion

  11. Solute Clearance: Rate of removal from the Blood • Information on Kidney Function • GFR • Reabsorption rates • Secretion rates Figure 19-16: Inulin clearance

  12. Excretion: All Filtration Products that are not reabsorbed • Excess ions, H2O, molecules, toxins, "foreign molecules" • "nitrogenous waste": NH4+ and excess urea • Kidney Ureter  bladder urethraout of body

  13. Excretion: All Filtration Products that are not reabsorbed Figure 19-5: The filtration fraction

  14. Urination: Micturation reflex • Bladder: • smooth muscles • internal sphincter • external sphincter • Regulation

  15. Urination: Micturation reflex Figure 19-18: The micturition reflex

  16. Summary • Kidney produces urine, ureter bladder urethra • Nephron filters, reabsorbs, secretes and excretes • Arteriole pressure dictates GFR through autoregulation, ANS and hormonal influences • Most filtrate is reabsorbed & returned via peritubular blood vessels; excess & toxic remains are excreted • Urination reflex uses involuntary and voluntary paths

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