1 / 8

Candesartan in Heart Failure

CHARM Trial. Candesartan in Heart Failure. Presented at European Society of Cardiology 2003. CHARM Trial. 7,601 patients with heart failure 3 Individual component randomized trials with the ARB candesartan (4 or 8 mg/day, titrated to target dose of 32 mg) or placebo. CHARM Preserved

rosa
Download Presentation

Candesartan in Heart Failure

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CHARM Trial Candesartan in Heart Failure Presented at European Society of Cardiology 2003

  2. CHARM Trial 7,601 patients with heart failure 3 Individual component randomized trials with the ARB candesartan (4 or 8 mg/day, titrated to target dose of 32 mg) or placebo • CHARM Preserved • Patients with LVEF >40% with or without ACE-inhibitor • CHARM Added • Patients with LVEF <40% and treated with an ACE-inhibitor • CHARM Alternative • Patients with LVEF <40% and ACE-inhibitor intolerant • Endpoints (follow-up minimum 2 years): • Primary – Component trials: cardiovascular mortality or CHF hospitalization • Primary – Overall trial results: All-cause mortality European Society of Cardiology 2003

  3. CHARM Overall Program CV Mortality orCHF Hospitalization HR 0.84 p<0.0001 All-cause mortality HR 0.91 95% CI 0.83-1.00 p=0.055 European Society of Cardiology 2003

  4. CHARM Added Trial CV Mortality HR 0.84 p=0.02 CV Mortality or CHF hospitalization HR 0.85 p=0.011 European Society of Cardiology 2003

  5. CHARM Alternative Trial CV Mortality or CHF hospitalization HR 0.77 p=0.0004 CV Mortality HR 0.85 p=0.072 European Society of Cardiology 2003

  6. CHARM Preserved Trial CV Mortality or CHF hospitalization HR 0.89 p=0.118 CV Mortality HR 0.99 p=0.918 European Society of Cardiology 2003

  7. CHARM Trial • CHARM Overall: Among symptomatic heart failure patients, treatment with ARB candesartan was associated with lower CV mortality and a trend toward lower all-cause mortality compared with placebo • CHARM Added: Among patients with symptomatic heart failure and an ejection fraction <40% treated with an ACE-inhibitor, additional treatment with the ARB candesartan was associated with reduction in the primary endpoint of cardiovascular death or heart failure hospitalizations

  8. CHARM Trial • CHARM Alternative: Among patients with symptomatic heart failure and an ejection fraction <40% who were ACE-inhibitor intolerant, treatment with the ARB candesartan was associated with reduction in the primary endpoint of cardiovascular death or heart failure hospitalizations • CHARM Preserved: Among patients with symptomatic heart failure and an ejection fraction >40%, treatment with the ARB candesartan was associated with a non-significant reduction in the primary endpoint of cardiovascular death or heart failure hospitalizations

More Related