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Explore the macrostructure and microstructure of skeletal muscle, the sliding-filament theory of muscular contraction, fiber types, muscle action types, and the role of connective tissue. Learn how calcium and ATP contribute to myosin cross-bridge cycling and force production. Discover the factors affecting muscle force and the different arrangements of muscle fibers.
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1 C H A P T E R Muscle Physiology
Chapter Outline Skeletal muscle macrostructure and microstructure Sliding-filament theory of muscular contraction Fiber types Types of muscle action Force production
Three Types of Connective Tissue:Epimysium, Perimysium, and Endomysium
Detailed View of Myosin and Actin Protein Filaments in Muscle
The discharge of an action potential from a motor nerve signals the release of calcium from the sarcoplasmic reticulum into the myofibril, causing tension development in muscle.
Calcium and ATP are necessary for myosin cross-bridge cycling with actin filaments.
Type II, or fast-twitch, muscle fibers are capable of developing higher forces than Type I, or slow-twitch, muscle fibers—especially at higher velocities of muscle action.
The number of cross-bridges that are attached to actin filaments at any instant in time dictates the force production of a muscle.
Three Arrangements of Muscle Fibers Fibers parallel to tendon Bipennate muscle Unipennate muscle
Many factors may affect rate of cross-bridge cycling and thus force, including neural activation, calcium concentration, myosin ATPase activity, preloading, prestretch, muscle fiber type and ultrastructure, fatigue through a variety of mechanisms, and number of contractile components (myosin and actin) in parallel.