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CREST

CREST. Primary outcome (death, MI, stroke at 30 days + ipsilateral stroke at 4 years) was similar between CAS and CEA arms (HR 1.11, 95% CI 0.81-1.51, p = 0.51) At 30 days, major strokes: 0.9% vs. 0.6%, p = 0.52; minor strokes: 3.2% vs. 1.7%, p = 0.01; MI: 1.1% vs. 2.3%, p = 0.03

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CREST

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  1. CREST Primary outcome (death, MI, stroke at 30 days + ipsilateral stroke at 4 years) was similar between CAS and CEA arms (HR 1.11, 95% CI 0.81-1.51, p = 0.51) At 30 days, major strokes: 0.9% vs. 0.6%, p = 0.52; minor strokes: 3.2% vs. 1.7%, p = 0.01; MI: 1.1% vs. 2.3%, p = 0.03 Long-term stroke rate: 2.0% vs. 2.4%, p = 0.85 (p = 0.85) (p = 0.51) Trial design:Patients with significant carotid artery stenosis were randomized to either carotid artery stenting (CAS) or carotid endarterectomy (CEA). Clinical outcomes were compared at 4 years. Results 10 10 7.2 6.8 5 5 Conclusions % % • CAS was associated with similar outcomes compared with CEA. Largest trial on this topic; different from earlier trials • Results true for both genders, and irrespective of symptoms • Left to be seen if CMS reconsiders coverage decision on CAS based on this study 2.4 2.0 0 0 Primary outcome Long-term stroke CAS (n = 1,271) CEA (n = 1,251) Brott TG, et al. N Engl J Med 2010;May 26:[Epub]

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