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Research Preparedness and Response to Emerging Pathogens Stock- taking and Perspectives

Research Preparedness and Response to Emerging Pathogens Stock- taking and Perspectives. Institute of Microbiology and Infectious Diseases Bernadette Murgue Yazdan Yazdanpanah Jean François Delfraissy. Time-series in research. Research Preparedness. Funding begins. Funding ends.

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Research Preparedness and Response to Emerging Pathogens Stock- taking and Perspectives

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  1. ResearchPreparedness and Response to EmergingPathogensStock-taking and Perspectives Institute of Microbiology and InfectiousDiseases Bernadette Murgue YazdanYazdanpanah Jean François Delfraissy

  2. Time-series in research Research Preparedness Funding begins Funding ends Research Response

  3. The challenge of emerging infectious diseases SARS: Severeacute respiratory syndrome , H1N1 influenza pandemic West Nile Clostridium difficile 027, Dengue fever, acute hemolytic-uremic syndrome caused by Escherichia coli, H7N9 influenza, MERS-CoV, Chikungunya

  4. SARS and H1N1: Lessonslearned • SARS: 2003 • Rapid identification of a novel virus • Rapidunderstanding of transmission; impact on response • first experience of multi-agencyresponse: WHO • H1N1 pandemic: 2009 • Unexpectedseverity, unusualsymptoms • Rapid recognition of a novel influenza virus: CDC • Lack of international research collaboration

  5. Researchresponse to the H1N1 pandemic in France 30 researchprojects - Cohort studies - Case-control studies - Serosurveys - Vaccine trials - Severe disease: ARDS - Social and Human Sciences - Diagnostics - Basic research €13m Total funding • Public: Inserm, Ministries Research and Health, ANRS • Private: Roche, GSK, FondationMérieux

  6. H1N1 response: mixed results • Strengths: more than 60 publications • Weaknessess: • Non-availibility of scientists • Shortage of social scientists • Ethical and regulatory issues • Lack of specificfunding • Obstacles to international collaboration • Communication gaps

  7. H1N1: lessonslearned • Contingency plan for researchresponse • Organization and coordination • Emergency fundingduringcrisis • Reactivity and flexibility

  8. French initiative to fight against emerging infectious diseases REACTingResearchandACTion targeting emerging infectious diseases

  9. Objectives • Improveresearchpreparedness • Integrateactivities • Improve communication • Stimulate global researchleadership • Timely initiation of research projects and funding

  10. REACTing • Not focused on one particular disease • Emerging human and zoonotic infections • Not focused on a particular area of research • Surveillance, modelling, economics, communication etc. • Not focusedon northern countries • Platforms, surveillance etc. in Southern countries

  11. REACTing: a consortium IBEID HIDDEN SPIL/CMIT

  12. Researchpreparedness • Set up a governance: reactivity, flexibility • Preparation of research tools • Identification of research priorities: likely scenarios of emergence • Establishment of links between different disciplines • Identification of potential sources offunding • Anticipation of legal and ethical issues

  13. In times of crisis… • CoordinateResearch • Definestrategicpriorities • Providemethodological assistance • Respondto requests of relevant authorities • Providecomprehensiveinformation to the public • Additionalfunding

  14. In at the deep end!Chikungunya in the Caribbean 2013 • First cases: December5th (St. Martin) • First meeting: December 20th • Working groups implemented • Researchprioritiesidentified • Seed money secured First record of autochtonoustransmission in the New world

  15. What’snext? H7N9? H10N8? Others?

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