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IMAGING AMPULLOMA OF VATER’S PAPILLE SERIES OF FIFTEEN CASES

GI8. IMAGING AMPULLOMA OF VATER’S PAPILLE SERIES OF FIFTEEN CASES. YAHDI VICHE, R SAOUAB, J EL FENNI, S. CHAOUIR, T. AMIL, A HANINE, B RADOUANE Radiology Service Instruction Military Hospital Mohammed V

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IMAGING AMPULLOMA OF VATER’S PAPILLE SERIES OF FIFTEEN CASES

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  1. GI8 IMAGING AMPULLOMA OF VATER’S PAPILLE SERIES OF FIFTEEN CASES YAHDI VICHE, R SAOUAB, J EL FENNI, S. CHAOUIR, T. AMIL, A HANINE, B RADOUANE Radiology Service Instruction Military Hospital Mohammed V In collaboration with the visceral surgery service (Sair Pr)

  2. INTRODUCTION • The ampullomasvatériens = often malignant or benign tumors derived from the intersection area bounded by biliopancreatic tract and the sphincter of Oddi (the last 2cm of the biliopancreatic junction) • Biliary obstruction is early clinical symptoms • The cross-sectional imaging is a great contribution to the diagnosis, staging and monitoring • Early diagnosed , the prognosis is better than pancreatic cancer

  3. OBJECTIVES • To report the clinical and epidemiological aspects of ampullomas vatériens in the series. • Establish the role and limitations of each imaging system. • Describe aspects of imaging ampullomas vatériens. • Discuss the differential diagnosis.

  4. Materials and Methods • Retrospective review of records of ampullomas vatériens explored in the training. • During 6 years period [January 2005 - December 2010]. • The image system used: - Ultrasound (n: 15) - CT (n: 11) - MRI (n: 4) - Endoscopic retrograde cholangiography (n = 4).

  5. RESULTS • 15 cases of ampulla vatériens were detected • Their representation are: - 0.2% of hospitalizations in the department of visceral surgery - 3.4% of digestive cancers (rank 8) • Average age: 68 years [ Between 52ans and 89ans] • 9 Males and 6 Female

  6. RESULTS The clinical symptoms were mostly dominated by cholestatic jaundice: • Cholestatic Jaundice 100% • Disorders of transit 46% • AEG 66.60% • Abdominal pain 40% • Fever 13% • Melaena 26.60%

  7. RESULTS Ultrasound Imaging

  8. RESULTS CT Imaging • The ampullary tumor was detected in 6 cases: - Process hypodense bulging through the duodenal wall: 4 patients (36.3%) - Barrier tissue density of the lower bile duct: 2 patients (16.6%). • Flooding pancreas: 2 cases • Lymph node metastasis: 2 cases • Visceral metastases: 1 patient

  9. RESULTS Case 1: Abdominal CT in axial(a), Reconstruction with frontal (b), C +: Tissue process of duodenal papilla, enhanced homogeneously, causing a dilation of a EHBD.

  10. RESULTS Case 2: Abdominal CT in axial, C +: Dilatation of intrahepatic bile ducts and extrahepatic upstream of a process of lower bile duct tissue coming in contact with the posterior wall of D3

  11. RESULTS Case 3: 40 years old man, obstructive jaundice Abdominal CT in axial, C-(a, c) / C + (b, d): Tissue mass of the pancreatic duodena's block, is moderately enhancing after injection of Pc and invading the pancreatic head, and he joins in a slight bile duct dilatation (d). ADK poorly differentiated ampullary

  12. RESULTS Case 3: one year later Increasing the size of the process with ampullary appearance of liver metastases

  13. RESULTS Case 4: 62 year old man; obstructive jaundice + GI bleeding Abdominal CT in axial, C-(a, c) / C + : Large mass enhanced after injection, bulging into the duodenal lumen and invading the biliopancreatic junction (arrow) with dilatation of upstream bicanalaire (arrow heads)

  14. RESULTS MRI Imaging • The ampullarytumorwasmentioned in 3 cases Dilatation of the CBD and upstream IHBD a circumferential thickening with stenosis of the lower bile regularly. The main pancreatic duct is not dilated

  15. RESULTS endoscopy histology Adenocarcinoma in all cases CPD: 9 cases (Cephalic pancreato-duodenectomy) Surgery bypass: 5 cases Endoscopic bypass: 1 case evolution • Death: 2 cases (5 to J and J 10)• Tumor recurrence: a case (15 months) • Death: 3 cases (5 months, 6 months and 9 months) • Death at 4 month

  16. DISCUSSION

  17. Anatomy 1. Choledocho-wirsungo-duodenal junction and sphincter of Oddi: Headquarters: middle part of D2 at the junction of the posterior and inner surfaces Variations: Low set, sometimes at D3 The lower part of channels is surrounded by the sphincter of Oddi. This block sphincter is located at a true dehiscence of the duodenal wall: the "duodenal window." The posterior part is low Frequency diverticulum at this level

  18. ANATOMY 1. Choledocho-wirsungo -duodenal junction and sphincter of Oddi The system terminal pancreatic duct is less and ventral to the common bile duct The type of anastomosis of the two channels is variable: common channel (60%); gunmetal at the top of the papilla (38%); separate duodenal anastomosis (2%) RadioGraphics 2002; Volume 22 ● Number 6

  19. Anatomy 2.The pancreatic duodenal block : The pancreas with its reports (after L. Testut, Human Anatomy). • A, pancreas, has with his head, and B, duodenum, C, jejunum, D, gallbladder;• 1, pancreatic duct, 2, accessory pancreatic duct, the arrow indicates its opening in 2 ', on the posteromedial wall of the duodenum, 3, ampullary, 6, hepatic duct, 7, aorta; 8, mesenteric vessels higher; 9, celiac trunk with three branches.

  20. Epidemiology The ampullary vatérien is a rare tumor: 0.02 to 5% of gastrointestinal tumors Peak age between 50 and 70 years with slight male predominance Predisposing factors: Familial adenomatous polyposis (ampullary adenoma in 50% of cases) Gardner's syndrome Van Recklinghausen's disease The association with cholelithiasis is found in 8-20% depending on the series

  21. Pathology The region tumors vatérienne can develop from the bulb itself or from the duodenal mucosa, pancreas and bladder. Gross pathology: two types of developmentIntra-duodenal (2/3 of cases): the tumor may be polypoid or vegetative (30%), submucosal (26%) or ulcerated Intra-papillary (1/3 of cases): strictly localized to the ampulla of Vater Microscopy: ampullary tumors are malignant in 95% of cases dominated by adenocarcinomas Sprouting aspect of the papilla at endoscopy performed in one patient in our series

  22. Pathology • TNM Classification: UICC 2002

  23. PATHOLOGICAL ANATOMY • TNM Classification: UICC 2002 T1 (a)Tm limited to the ampulla of Vater or sphincter of Oddi T2 (b)Tm invading the duodenal wall T3 (c)Tm invading the pancreas 2 cm or less Q4 (d)Tm invading the pancreas more than 2 cm and / or adjacent organs

  24. Clinical The obstructive jaundice: it is the sign most frequently revealing and often constant, found in 70-80% of cases GI bleeding: Sx evocative but inconstant (6% of cases), melaena, anemia Other: abdominal pain, transit disorders, IGC

  25. Imagery 1.Échographie: Review of first-line before a cholestatic jaundice Interest: Confirm the dilated bile ducts in 100% of cases with hydrocholecyste Specify the level of obstruction in 90% of cases View ampullary tumor in 25% of cases especially if the tumor size> 2 cm To identify liver metastases Limits: Tumors <2 cm The nodal The interposition gas or obesity + + +

  26. Imagery 2.Echoendoscopie: Technical: Use of a transducer rotating scanning high frequency. In recent years, development of mini probes of 2 mm diameter and high frequency (20MHz)  Possibility of retrograde catheterization of the bile and pancreatic ducts and Possible distinction between the sphincter of Oddi and duodenal mucosa in NB: the risk of nodal involvement is zero in case of tumors limited to the sphincter Mini probe intra ductal (1: sphincter of Oddi). Mini probe intra ductal (1: sphincter of Oddi). NB: the risk of nodal involvement is zero in case of tumors limited to the sphincter

  27. Imagery 2.Echoendoscopie Interest: The visualization of the tumor vatérienne in 90 to 100% of cases Superior sensitivity than other imaging techniques for evaluation of: - The extension of the tumor (T): if malignancy crossing the fourth hypoechoic layer of the duodenal wall (muscularis) - The nodal (N): diagnostic accuracy of 68 to 76% for stage N1 - The invasion of the vein axis mesocaval door with a sensitivity of 91% and a specificity of 97% Indications: Suspicion of pathology with an ampullary OGDF a cross-sectional imaging and inconclusive Assessment of preoperative extension of ampullary tumors proven choice of TRT (surgical or endoscopic)

  28. Imagery 3.TDM: Importance: Sensitivity of 85 to 90% in case of biliary dilatation and specificity of 90%. Technical: Acquisition helical thin sections Ingestion of water + + + Study with and without injection of the PC in arterial and portal venous phase (with 100cc flow 3cc/sec) Results: Positive diagnosis: Turgid appearance of the papilla or hypodense heterogeneous process bulging into the duodenal lumen The dilated bile ducts inside and outside the liver associated with dilatation of the pancreatic duct is highly suggestive of the diagnosis Extension: The pancreas, lymph node, peritoneal or hepatic vein thrombosis

  29. Imagery MRI Interest: better contrast resolution and multi planar study Technical: morphological sequences: axial acquisitions SPT1 and FAT-SAT GADO T1, T2 Sp coronal acquisition, 4mm thick Sequence diffusion and Bili-sequence MRI Results: MRI allows visualization of the ampullary tumor in 93% of cases: Small polypoid lesion, iso or hypo T1 and T2, weakly or moderately enhanced after injection protruding into the duodenal lumen Sometimes, a simple engorgement of the papilla Irregular thickening of the biliopancreatic junction The bili-MRI appreciate the topography and the length of the obstacle. Frank said in a ruling "pellet shells" referred to the diagnosis.

  30. Imagery 5. Other a. UGI: Images evocative: The gap tumor protruding into the duodenal lumen.The classic image epsilon (sign Frosberg or "reverse 3") ulceration within a tumor proliferation. Images nonspecific: The irregular stenosis of the duodenum by discussing the second duodenal cancer; Expansion of the duodenum; Printing bulbar post a bile duct dilatation

  31. Imagery 5.Other: b. Cholangiographie Retrograde Endoscopic (ERCP) It allows: To objectify stricture or bile duct or ampullary gap in intra papillary forms that go unnoticed at duodenoscopy. To complete the review by a wirsungographie possible.

  32. Differential Diagnosis Neoplastic causes: Cancer of the pancreas head The lower bile duct Cholangiocarcinoma Cancer duodenal Non-neoplastic causes: Lithiasis of the CBD; Barrier parasite: cyst, roundworms or flukes. Sclerosing cholangitis; Pancreatitis Inflammatory stenosis of the bile duct. Sphincter of Oddi dysfunction: about 5% of patients suspected of having a DSO have an ampullary; Diverticulum juxta-ampullary: lithiasis and thus promotes misdiagnosis. Benign papilla papilla 'forced' migration after gallstone.

  33. Differential Diagnosis 1.Cancers peri-ampullary: a. Carcinome pancreatic: pancreatic mass: hypovascular, often with an infiltrative lymph node status. The expansion bicanalaire qq with special features:Sx of four segments: visualization of biliopancreatic channels upstream and downstream of the tumor The pancreatic duct dilatation secondary

  34. Differential Diagnosis 1.Cancers peri-ampullary: b. Cholangiocarcinome: Irregular thickening of the bile duct wall or intraluminal polypoid mass The distal common bile duct is often visible sign 3 segments (2 segments of the bile duct + pancreatic duct non-dilated)

  35. Differential Diagnosis 1.Cancers peri-ampullary: c) duodenal Cancers: Uncommon tumor It can be polypoid, ulcerated or infiltrative Lymph Nodes in 22-71% of cases The duct dilatation biliopancreatic is moderate or absent

  36. Differential Diagnosis 2. Papillary inflammation: Multiple causes: passage + + + gallstones, cholangitis, pancreatitis or acute infectious (parasitic) Swollen appearance of the papilla with homogeneous enhancement 3. Tumeur intra ductal papillary mucinous pancreas (IPMT): Papillary epithelial proliferation, benign or malignant mucin-producing ductal dilatation Peak age of 60 years with male predominance Imaging: papilla large (> 10 mm) with multicystic dilatation of the pancreatic duct and mural nodules

  37. Differential Diagnosis 4. Other: choledochal cyst Intraoperative view after a duodenotomy cholédochocèle, the ampullary ≠ vatérien Subsidence choledochal cyst after dilation of the papilla. (Iconography of surgery visceral I)

  38. Treatment The treatment of choice remains wide surgical excision CPD type (cephalic pancreatico-duodenectomy) unless otherwise-cons: Vascular invasion. Remote node metastases (<5%) Métastases liver (5-10%) Peritoneal carcinomatosis Duodenopancretactomie cephalic part. (Iconography of surgery visceral I)

  39. Treatment Other methods: The endoscopic ampullectomy Tm small ampullary benign or malignant is not invading the submucosa duodenal Endoscopic sphincterotomy diagnostic, therapeutic preoperative or palliative therapy Biliary drainage + / - stent grafts: Tm locally advanced Radio-chemotherapy: adjuvant TRT after surgical resection or as palliative

  40. Evolution and prognosis The prognosis is better compared to other peri-ampullary cancers. It is mainly related to nodal involvement. The prognosis is greatly improved by early treatment attitude and thoughtful. The average survival to 5 years is directly related to tumor stage and nodal involvement.

  41. Conclusion The ampulloma vatérien is a rare tumor, often malignant. Always think before a cholestatic jaundice + GI bleeding. Ultrasound is the first review confirm biliary obstruction and determine the level of obstruction. CT, MRI with MRI-Sq Bili are fundamental for the diagnosis and staging. The echo-endoscopy is a great thing if the cross-sectional imaging is inconclusive

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