What is Genetic Doping

1. WhatisGenetic Doping An easy and practical way to understand it !!

2. The Problem….. • Letusbeclear, DG as most of thesubstancesthat are bannedhave a quality .... Their original use wasto cure orimprovediseases, eg: • 1.- EPO, Treatment in severe anemias orsome Tumoral processes • 2.- Anabolicsteroids: AIDS and severe anemias • 3.- Insulin: Diabetics • 4.- Diuretics: Hypertension and HeartFailure • 5.- ACTH; AddisonEnf, Cushing Sind • 6.- Amphetamines: Obesity, Narcolepsy, ADHD • Etc, etc., etc.

3. The illuminated • But one day someone thought ..... and if I get out, I bleed with a good amount of oxygen, and still the centrifuge and I only stay with the reduction? I will have more oxygen for less effort;) • Unfortunately, the majorities of the substances I mentioned earlier, at the time were classified as legal, until they began to see the effects and not the studies: Oh s…….!

4. The Race against the clock • The controls • According to the WADA with a percentage between 3.53 among the Labs, Laussane and Koln have been the most samples of BP have received. Only laboratories in Europe have received more than 135,911 samples between Biological, Hematological and Urine Passports, while Asia with 61.1% of the world population, only 43,867 samples have been carried out in their laboratories, only one third of all Europe (According to WADA Annually publishes statistical reports as reported by the WADA accredited laboratories in ADAMS) • This added to the research budget (in 2009 year of PB strengthening) was just $ 25 million) https://www.wada-ama.org/sites/default/files/resources/files/PlayTrue_2009_2_Special_Tenth_Anniversary_SP. Pdf • Where conflicts began because the stored samples could be registered as legal evidence before the TAS • Given this problem and comparing that only a Cycling team that is mentioned in the magazine arueda.com is about 35 million a year, we can understand why the race of Doping goes against the clock

5. But why Genetic Doping? • Ironically Genetic Doping has been included in the list since 2003, but the interpretation or the result of the tests is impossible since it is to say, that an athlete can not use insulin because it is Diabetic, bone is part of its genome element, the Which we will explain below. Let us divide it in two: • 1.- A convertor of angiotensin, which raises peripheral vascular resistance, is used in many drugs to control the tension, so that for more cardiac output the athlete will have an Enzyme to control it, EPO of which already We know ... .as they listen, they can include it in the system without being able to avoid being part of it and not being discovered. • 2.- Then would be the two most interesting genes because it acts directly on the muscle: The mechanical growth factor, Growth Hormone for muscle mass

6. Imagine that our Human Genome is a wall, which most are defects, are not perfect, and their base could be somewhat unstable. 1.- The Enzymes converter and the EPO would be the bricks of blue, would reinforce the weak points would even support in case of leaning before any on on effort of the wall 2. But the Royal Base, would be the Hormone for mechanical mass, is the foundation, of a structure, almost perfect ... ..now, you imagined that this wall is the size of the Empire State, as you would know Which brick is the anomalous? That is why it is not infallible, but if it is true that it is very difficult to get the Gene resulting from the change in Genetic Doping

7. What to do ?? From the alleged doubt or suspicion? 1.- Starting from the benefit of the doubt, most agencies have a way to see the evolution of athletes and usually protect the young promises that are coming up progressively, so that the introduction to a state program Should be prior study of the medical history evaluation. We already understand that this would have to change everything that is the data protection law. But a follow-up even when already 16 years old would give us much guarantee of being able to observe or discover significant changes in its molecular density. 2.- DNA analyzes would confirm the dominant gene in a familiar 3.- Continue with the policy of preserving 10 years shows, possibly in a few years we can reach the goal of being able to detect this type of Doping. 4.- All athletes should sign a basic document to the economic complex and responsibility of fair play. 5.- The TAD and the Spanish Agency should not pronounce on precautionary measures, this is not a defense of citizens is simply that for one reason or another must have the benefit of the doubt

8. How to Improve Controls 1.- I could summarize everything by saying that by complying with the International Standard for Controls and Research, but it would be a bit of a bummer. This was done for situations where there are no legal and normative internal figures that intervene in them. 2.- The OCD should take part in the investigation, if, that is, although it does not create it is the only link between the athlete and the Test Autority, only in our times no longer exists that figure, since the sub contracts you do Of test responsabillity is not only that determines the rules of the game but the one that realizes in OCD Report, that should arrive intact to the Test Autority but is not usually so in some cases. 3. According to the WADA Code in Article 2.6, possession of a substance makes it a violator of the Anti-Doping Code (How many people enter the privacy of a residence under the law) 4.- Modify Annex H of the International Standard of Controls and Research, thus providing the OCD to be able to have the benefit of veracity in case of controls 5.- Initiate controls more precoz and thus be able to dissuade the athletes who are going up in relation to the measures and regulations 6.- Invest more in genetic engineering research in relation to the subject, which will lead to seek a different method of financing or to carry out clinical agreements with specialized centers on this topic. 7.- Better adjustment of the protocols in the Regulations of Controls; Something that we could learn from 2000-2010 is that the presence of the DCO is impossible to go unnoticed in a concentration, so the massive controls (Go to a region for more than 5 athletes who run or participate in the same sport is not Very practical (although if profitable for the collecting companies)

9. Conclusión 1. From the time of the first steps against Doping, the desire to go further by chemical, genetic and mechanical means has resulted in the investment of those involved in a way that the movement is no longer as deterrent As it was in 2000. 2. The independence of the WADA with respect to other organisms should be omnipresent at all levels (including budgetary ones) 3. The increase of Independent Observers should result in addition to the aid in large concentrations, the audit of the systems, since each collecting company can have a difference in their methods and work in unison should be 100% 4.- The search for a new financing system compared to the current one, increasing by 33% of controls in areas where ORAs can not supply the statistics of 1.3 controls per federate (According to statistics from 2015) 5.- Carry out an evaluation by efficiency index according to the area of ​​the ORA to optimize the results 6.- Create an External Audit Office at the Regional level