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e stradiol supplementation. Figure S1. Growth chart of the patient. Actual height of the patient is plotted against the growth curve for Japanese girls (the mean, ± 1.0 SD and ± 2.0 SD). p = 0.78. p = 0.06. p = 0.20. p = 0.97. p = 0.02. p = 3.2×10 -7. p = 1.2×10 -7.
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estradiol supplementation Figure S1. Growth chart of the patient. Actual height of the patient is plotted against the growth curve for Japanese girls (the mean, ± 1.0 SD and ± 2.0 SD).
p = 0.78 p = 0.06 p = 0.20 p = 0.97 p = 0.02 p = 3.2×10-7 p = 1.2×10-7 p = 1.1×10-4 p = 7.0×10-7 p = 1.1×10-13 Relative fold induction Relative fold induction p = 6.0×10-8 p = 2.0×10-7 WT (ng/well) 0 2020 100 WT (ng/well) 0 2020 100 MT (ng/well) 0 0 20 10 20 MT (ng/well) 0 0 20 10 20 PAX3 (-) PAX3 (+) Figure S2. In vitro reporter assay using a luciferase vector containing the MITF promoter. The SOX10 expression vectors were transfected with (right panel) or without (left panel) the PAX3 expression vector. The results are expressed as the mean ± one standard deviation. The p.Pro169fsX117 mutant (MT) barely transactivated the MITF promoter and exerted no dominant-negative effects on the wildtype (WT) SOX10 protein. As controls for the expression vectors, an empty counterpart vector was transfected.