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Nytta och risk med konsumtion av fet fisk Uppsala, okt.2002

Nytta och risk med konsumtion av fet fisk Uppsala, okt.2002. Jørn Dyerberg Hjärta/kärlaspekter, omega-3-fettsyror. Age standardised death rates in per cent of all deaths from IHD in males aged 45-64 years Figures in Greenland based on the years 1974-76. Lancet 1971; 1:1143-6.

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Nytta och risk med konsumtion av fet fisk Uppsala, okt.2002

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  1. Nytta och risk med konsumtion av fet fiskUppsala, okt.2002 Jørn Dyerberg Hjärta/kärlaspekter, omega-3-fettsyror

  2. Age standardised death rates in per cent of all deaths from IHD in males aged 45-64 yearsFigures in Greenland based on the years 1974-76.

  3. Lancet 1971; 1:1143-6

  4. Fatty acid composition of plasma phospholipids in Greenland Eskimos GE and Danish controls D. Values are means as per cent of total (Am J Clin Nutr 1975;28:958-66)

  5. Lancet 1978; 2:1179

  6. Distribution of fatty acid classes in Danish and Eskimo food and blood platelets Food Omega-6 class__________________________________ Omega-3 class__________________________________ Platelets Arachidonic acid (Omega-6)_______________________ Eicosapentaenoic acid (Omega-3)___________________ Bleeding Time_____________________________________ Eskimos 5,4 g/day 13,7 g/day 8,5 % 8,0 % 8,1 min Danes 10,0 g/day 2,8 g/day 22,1 % 0,5 % 4,7 min Lancet 1979;2:433-5

  7. The effect of n-3 PUFA supplementation on bleeding time (BT) in normals and different patient groups • Kristiansen et al. Atherosclerosis 1987; 13-9 • Schmidt et al. J Intern Med 1989; (suppl 1) : 201-6 • Schmidt et al. Thromb Haemostas 1989; 62: 797-801 • Schmidt et al. Clin Chim Acta 1990; 189; 25-32 • Schmidt et al. Thromb Haemostas 1990; 63: 1-5 • Mortensen et al. Thromb Haemostas 1983; 30: 543-6.

  8. Gissi-Prevenzione trial 11324 patients randomised 2830 given n-3 PUFA 2830 given vitamin E 2830 given n-3 PUFA plus vitamin E 2828 controls 3 lost to follow-up 768 discontinued n-3 PUFA 4 lost to follow-up 687 discontinued vitamin E 11 received n-3 PUFA 4 lost to follow-up 848 discontinued n-3 PUFA 808 discontinued vitamin E 2 lost to follow-up 15 received n-3 PUFA 2 received vitamin E 2836 analysed for outcomes 2830 analysed for outcomes 2830 analysed for outcomes 2828 analysed for outcomes Figure 1: Trial profile Lancet 1999; 354: 447-55

  9. GISSI – Preventione TrialResults (RR Four-way analysis) Lancet 1999;254:4475-5

  10. Special Report Heart Rate Variability Standards of Measurement, Physiological Interpretation, and Clinical Use Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology • “Because 24-hour HRV indices appear to be stable • and free of placebo effect, they may be ideal variables • to assess intervention therapies” • “A powerful predictor of SCD” Circulation 1996;93:1043

  11. Omega-3 fedtsyrer og pludselig hjertedød Patienter med AMI og EF < 0.40 SDNN (ms) 1. kvartil 2.-3. kvartil 4. kvartil lav høj mellem DHA i trombocytter (Am J Cardiol 1997;79:1670)

  12. HRV and DHA in healthy men r = 0.50, p<0.01 ---------Lowess regression ______linear regression r = 0.68, p<0.001 in the interval 1.3<DHA<2.1 Content of DHA in granulocytes Am J Clin Nutr 1999;70:333-7

  13. Am J Clin Nutr 1999;70:331-7

  14. Marine n-3 Fatty Acids, Wine Intake, and Heart Rate Variability in Patients Referred for Coronary Angiography Circulation 2001;103:651 • 295 patients referred for elective coronary angiography • Food questionnaire and drinking habits • Adipose tissue biopsy (n-3 fatty acids) • Granulocytes and platelets (n-3 fatty acids) • 24-hour HRV

  15. Table 2. Fish Consumption (Fish Score) Related to n-3 PUFA Levels Cirkulation 2001; 103: 651-7

  16. Table 3. Univariate Nonparametric Correlation Coefficients Between Levels of n-3 PUFA in Adipose Tissue and in Granulocyte Membranes and HRV Indices in the 291 Patients Cirkulation 2001; 103: 651-7

  17. **: p<0.01, Kruskall-Wallis test

  18. **: p<0.01, Kruskall-Wallis test

  19. **: p<0.01, Kruskall-Wallis test

  20. Table 5. Linear Multiple Regression Analysis (Backward) With HRV Indices as Dependent Factors Cirkulation 2001; 103: 651-7

  21. H.O. Bang Aase Brøndum Ruth Edgar Niels Hjørne Jens Zobbe Mortensen Terkild Arnfred Poul Madsen Gunnar Lauge Nielsen Niels Svaneborg Kim Varming Jørn Munkhof Møller Erik Stoffersen Kaj Anker Jørgensen Steen Dalby Kristensen Troels Ring Torben Mourits-Andersen Niels Grunnet Casper Jersild Peter Bjerregaard Eva Korup Jens Aarøe Arne Høj Nielsen Sir John Vane Salvador Moncada Hugh M. Sinclair Gerard Hornstra Arne Nordøy Egon Toft Erik Ernst Erik Berg Schmidt Jeppe Hagstrup Christensen Videnskabelige medarbejdere gennem godt 30 år

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