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Content How cancer arises Pathways involved in cancer Genes involved in cancer

Lecture 5: Pathways in Human Cancer Y.Z. Chen Department of Pharmacy National University of Singapore Tel: 65-6616-6877; Email: phacyz@nus.edu.sg ; Web: http://bidd.nus.edu.sg. Content How cancer arises Pathways involved in cancer Genes involved in cancer Molecular targets of cancer

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Content How cancer arises Pathways involved in cancer Genes involved in cancer

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  1. Lecture 5: Pathways in Human CancerY.Z. ChenDepartment of PharmacyNational University of SingaporeTel: 65-6616-6877; Email: phacyz@nus.edu.sg ; Web: http://bidd.nus.edu.sg • Content • How cancer arises • Pathways involved in cancer • Genes involved in cancer • Molecular targets of cancer • Network-based drug design

  2. Integrated circuit of the cell

  3. How Cancer Arises?

  4. Pathways Involved in Cancer

  5. Pathways Involved in Cancer

  6. Pathways Involved in Cancer: Growth regulation

  7. Pathways Involved in Cancer: Growth regulation

  8. Pathways Involved in Cancer: Cell Cycle Control

  9. Pathways Involved in Cancer: Cell Cycle Control

  10. Pathways Involved in Cancer: Apoptosis

  11. Pathways Involved in Cancer: Apoptosis Regulation via Death Receptor

  12. Pathways Involved in Cancer: Apoptosis Regulation via Mitochondria

  13. Pathways Involved in Cancer: Regulation of Apoptosis, Inflammation and Stress Response

  14. Pathways Involved in Cancer: Multiple regulation

  15. Pathways Involved in Cancer: Multiple regulation

  16. Pathways Involved in Cancer: Cytoskeletal Signaling, Invasion and Migration

  17. Pathways Involved in Cancer: Wnt/β-Carenin Signaling, Adhesion and Migration

  18. Pathways Involved in Cancer: TGF-βSignaling: Regulator of Growth, Differentiation, Migration, Wound Healing

  19. Pathways Involved in Cancer: Energy Metabolism and Cell Survival

  20. Pathways Involved in Cancer:Immune Regulation

  21. Pathways Involved in Cancer:Immune Regulation

  22. Pathways Involved in Cancer:Immune Regulation

  23. Pathways Involved in Cancer:Immune Regulation

  24. The Cell Cycle Clock and Cancer

  25. The Cell Cycle Clock and Cancer

  26. Molecular Targets of Cancer

  27. Malignant Mutations from Pathway Perspectives

  28. Genes Involved in Cancer

  29. Genes Involved in Cancer

  30. Molecular Targets of Cancer

  31. Molecular Targets of Cancer: Human Kinase Overview

  32. Molecular Targets of Cancer: Human Kinase Overview

  33. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  34. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  35. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  36. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  37. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  38. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  39. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  40. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  41. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  42. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  43. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  44. Molecular Targets of Cancer: Kinase-Disease Associationshttp://www.cellsignal.com/reference/kinase_disease.html

  45. Network-Based Drug Design BioSystems 83, 81 (2006)

  46. Network-Based Drug Design BioSystems 83, 81 (2006)

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