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Humoral and Cellular Immunity

Humoral and Cellular Immunity. • Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids. . •Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.

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Humoral and Cellular Immunity

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  1. Humoral and Cellular Immunity •Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids. •Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.

  2. The Complement System Ricklin and Lambris 2007

  3. Functions of the Complement System •Viral neutralization

  4. The Complement System Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens Designation of complement components: numerals (C1-C9) letter symbols (factor D) trivial names (homologous restriction factor) cleavage products – “a” and “b”

  5. Complement Activation Pathways Immunobiology (Garland Science 2005)

  6. The Complement System Complement Activation:

  7. The Complement System

  8. The Complement System Classical Pathway requires antibody interaction:

  9. The Complement System

  10. Consequences of Complement Activation •The three complement pathways converge at the membrane-attack complex (MAC).

  11. Consequences of Complement Activation

  12. Regulation of the Complement System Regulation can occur at multiple steps in the complement system: Before assembly of convertase activity After assembly of convertase Assembly of membrane attack complex (MAC) Turnberg and Botto, 2003

  13. Microbial Evasion •Some microbes can evade complement-mediated damage. Schneider, et al 2007

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