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Herbicide Modes of Action. Eric P. Prostko Extension Weed Specialist Department of Crop & Soil Sciences The University of Georgia. April 2008. Some things to remember…. photosynthesis (food) respiration (energy) amino acids (proteins/growth) lipids (cell membranes)
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Herbicide Modes of Action Eric P. Prostko Extension Weed Specialist Department of Crop & Soil Sciences The University of Georgia April 2008
Some things to remember…. • photosynthesis (food) • respiration (energy) • amino acids (proteins/growth) • lipids (cell membranes) • pigments (energy/light capture) • chlorophyll, carotenoids • mitosis (cell division)
Mode of Action • the sequence of events that leads to plant death or growth interruption • 2 phases * movement to target site * interaction at target site
Mechanism of Action (Site) • Location at which a herbicide exerts its toxicity at the cellular level • more specific
ACCase Inhibitors • Inhibit acetyl-CoA-carboxylase (ACCase) enzyme • Enzyme needed for fatty acid synthesis • Dim’s and Fop’s • Achieve, Assure, Axial, Fusilade, Poast, Select
“rotted” meristem Source: W. K. Vencill, UGA
ALS Inhibitors • Inhibit acetolactate synthase (ALS) enzyme • enzyme needed to produce certain amino acids (isoleucine, leucine, valine)
Accent Ally/Cimarron Beacon Beyond Cadre Classic Envoke Exceed Express Finesse FirstRate Glean Harmony Extra Maverick Pro Osprey Peak Permit Pursuit Python Scepter Staple Strongarm Commonly Used ALS Herbicides
Cadre “yellow flash” Staple+ on Sorghum
Resolve 25WG (rimsulfuron) Injury to Field Corn Pictures @ 18 DAT 1.0 oz/A Applied PRE
Photosystem II Inhibitors • Inhibit photosynthesis by binding to QB-binding niche on D1 protein • Evik, Caparol, Atrazine, Basagran, Buctril, Direx, Cotoron, Lorox, Sencor, Simazine
Bladex Cotoran Source: W. K. Vencill, UGA
Photosystem I Inhibitors • Accept electrons from PSI to form radicals • Super radicals formed to create peroxides • Diquat, paraquat
Paraquat Source: Purdue University
PPO Inhibiting Herbicides • PPO or Protox • Protoporphyrinogen oxidase • Enzyme found in chloroplast and mitochondria needed for formation of chlorophyll • Cell membrane destruction • Many common herbicides have this mode of action!! • Ultra Blazer, Cobra, Goal, Reflex, Ronstar, Resource, Aim, Valor, Storm, Spartan, ET
Valor Injury on Peanut Blazer Injury on Peanut Cobra on Soybeans
Carotenoid Biosynthesis Inhibitors • Inhibit phytoene desaturase (PDS) or hydroxyphenyl pyruvate dioxygenase (HPPD) • Command, Callisto, Laudis, Solicam/Zorial, Impact
Command Zorial Laudis
EPSP Synthase Inhibitor • EPSP synthase needed for production of certain amino acids (tryptophan, tyrosine, and phenylalanine) • glyphosate
Source: Purdue University Weed Science Source: MSU Weed Science
Glutamine Synthetase Inhibitors • Glutamine synthetase converts glutamate and ammonia to glutamine • Causes ammonia accumulation in plants • Liberty, Ignite
Mitosis Inhibitors • Microtubule inhibition • Treflan, Prowl, Sonalan, Surflan, Dacthal • Inhibition of very long-chain fatty acids • Dual Magnum, Outlook, Intrro
Dual Injury Source: University of Wisconsin Weed Science
Fatty Acid and Lipid Biosynthesis Inhibitors • Inhibition of lipid synthesis (not ACCase) • Prefar, Sutan, Eptam, Eradicane, Ordram, Tillam, Bolero
Source: Purdue University Weed Science Source: UC-Davis Weed Science
Synthetic Auxins • Disrupt hormonal balance • 2,4-D, Banvel, Clarity, Status, Stinger, MCPA, Facet, Remedy, Grazon P+D
Source: Purdue University Weed Science Source: Purdue University Weed Science
Unknown MOA • DSMA, MSMA • Cell membrane destruction???
MSMA on Peanut MSMA on Zoysia
UGA Weed Science www.gaweed.com