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a bioactive interference screw for acl reconstruction

Problem Statement. The purpose of this project is to design an interference screw for ACL reconstruction that will promote and foster the growth of tissue and secure the graft.. Problem Motivation. Currently, the majority of interference screws are made of titanium or partially bio-degradable material. These materials may inhibit tissue growth or cause unwanted debris in the patellar region of the body.A minority of interference screws are composed of a mixture of bioactive materials and poly9459

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a bioactive interference screw for acl reconstruction

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    1. A Bioactive Interference Screw for ACL Reconstruction

    3. Problem Statement The purpose of this project is to design an interference screw for ACL reconstruction that will promote and foster the growth of tissue and secure the graft.

    4. Problem Motivation Currently, the majority of interference screws are made of titanium or partially bio-degradable material. These materials may inhibit tissue growth or cause unwanted debris in the patellar region of the body. A minority of interference screws are composed of a mixture of bioactive materials and polymers. These screws only promote tissue growth of small magnitudes.

    5. Design Constraints The screw must be: bioactive biocompatible easily sterilized or autoclaved biodegradable as tissue re-grows able to withstand the stresses involved in surgery and limited postoperative activity

    6. Background – ACL Reconstruction

    7. Background – Current Screws Most interference screws are titanium Bioactive interference screws are starting to be utilized Current bioactive screws degrade incompletely and asynchronously with tissue formation Both types have varying geometries and sizes Multiple companies produce these types of screws

    8. Background – Hydrogel Templates Water-based scaffolds used to mimic extracellular fluid Promote cell proliferation and tissue growth Can be differentiated with growth factors, nutrients, metabolites, etc. A mineralization process calcifies the hydrogel to meet mechanical demands Ultimate degradation replaces hydrogel with tissue

    9. Hollow Screw Shaft

    10. Producing The Hollow Screw Shaft

    11. Technique Alternative 1:Diffusive Membrane Application Mold is split into two halves Shaft-fitting semi-permeable membrane Hydrogel monomer injected into threads

    12. Technique Alternative 1:Diffusive Membrane Application Crosslinker poured onto membrane Induces gel state Re-attach mold halves Mineralization hardens gel (i.e. Ca2+) Remove membrane after setting Apply thermoplastic Hollow shaft

    13. Technique Alternative 2: Static UV Application Tube inserted into mold UV-activated crosslinker/hydrogel mixture UV light activates crosslinker Tube removed, mineralization occurs Thermoplastic application is carried out Mold is unhinged and screw is removed

    14. Technique Alternative 3:Rotational Application Hydrogel and UV-activated crosslinker The mold is rotated allowing solution to fill threads UV light polymerizes hydrogel Mineralization and thermoplastic application

    15. Technique Matrix

    16. Future Work Research methods for fabricating molds Continue researching the hydrogel process Develop a prototype mold Test various facets of molded interference screws Biocompatibility Degradation Structural Integrity Ease of development

    17. ?QUESTIONS?

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