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“ MONIKI ” named after M.F. Vladimirsky D. Kulikov , MD, PhD

Development of the method for evaluating the status of blood microcirculation system and the risk of microvascular complications development at diabetes mellitus based on optical spectroscopy. “ MONIKI ” named after M.F. Vladimirsky D. Kulikov , MD, PhD. Conclusions.

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“ MONIKI ” named after M.F. Vladimirsky D. Kulikov , MD, PhD

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  1. Development of the method for evaluating the status of blood microcirculation system and the risk of microvascular complications development at diabetes mellitus based on optical spectroscopy “MONIKI” named after M.F.Vladimirsky D. Kulikov, MD, PhD

  2. Conclusions • Informative functional tests as well as an algorithm of the registration for the investigation of the blood skin microcirculation at diabetes were developed • A method for processing and evaluating the results was also obtained.

  3. Diabetes Mellitus *Data from Diabetes Atlas,2013International Diabetes Federation (IDF) 5.1 million people died and 548 billion USD were spent due to diabetes in 2013 * 10,8% global healthcare expenditure ! Reactivemedicine Proactivemedicine at half-percent of cases patients already have different complications at the time of diabetes diagnosis It is time to SCREAM

  4. Laser Doppler Flowmetry to photo receiver from laser to photo receiver arterioles, 0.7-3.9 mm/s capillary, 0.1-0.6 mm/s venules, 0.3-1.2 mm/s LAKK diagnostic system Velocity

  5. Distribution of the basal Mean perfusion normalized in groups

  6. Sample sizecalculation, depending on standard deviation Supposing:  n=f(R,a)

  7. Occlusive test results Occlusion (start) Occlusion (stop) The relative increase in blood flow ControlPatients Recovery period Base flow registration Time (s)

  8. Combined occlusive+heating test results Occlusion (start) Occlusion (stop) Heating (41±C°) The relative increase in blood flow ControlPatients Recovery period Base flow registration Time (s)

  9. Combined heating+postural test on arms (methodology)

  10. Combined heating+postural test on arms (results) Lowering thelimb Back to initial position Raising thelimb The relative increase in blood flow ControlPatients Heating (41±C°) Recovery period Base flow registration Time (s)

  11. Combined heating+postural test on legs (methodology)

  12. Combined heating+postural test on legs (results) Back to initial position Lowering thelimb The relative increase in blood flow ControlPatients Heating (41±C°) Base flow registration Recovery period Time (s)

  13. Role of microcirculatory disorders in the pathogenesis of diabetes Microcirculatory disorders Insulinresistance Hyperglycemia Jorneskog et al., 2005 Clark, 2008 Fredriksson et al., 2010Czernichow et al., 2010 Jarnert et al., 2012

  14. Possible application points • Early diagnostics of DM and it’s complications • Control of sugar-lowering treatment efficiency

  15. Examples of information processing

  16. Inclusion/Exclusion criteria • Age • Body Mass Index • Term of illness • Micro/macrovascular complications in anamnesis • Pernicious habits (alcohol, smoking) • Arterial blood pressure level • Status of carbohydrate metabolism (compensation/decompensation) • Received treatment etc.

  17. “MONIKI” named after M.F. Vladimirsky • 200000 patients with DM in register • “Mobile Diabetes Center” • 3 000 patients with early disruptions in carbohydrate metabolism • Conducting research in context of a clinical survey • Long-term case monitoring

  18. Identifying signs for early diagnosis + symptomatic forms of DM (acromegaly, using of glucocorticoids, etc.)

  19. Important • Metrological aspects of the research • Functional tests • Forming studying and control groups

  20. Thank you for your attention! www.medphyslab.com zdolsk2@gmail.com

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