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CHAPTER 13 Renal Transplantation

CHAPTER 13 Renal Transplantation. Goh Bak Leong Fan Kin Sing Rohan Malek Bin Dato’ Dr. Johan Rosnawati Yahya S. Prasad Menon Tan Si Yen Wong Hin Seng. Source: 20 th MDTR Report 2012, NRR. Table 13.1.1: Stock and flow of renal transplantation, 1993-2012.

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CHAPTER 13 Renal Transplantation

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  1. CHAPTER 13 Renal Transplantation Goh Bak Leong Fan Kin Sing Rohan Malek Bin Dato’ Dr. Johan Rosnawati Yahya S. Prasad Menon Tan Si Yen Wong Hin Seng Source: 20th MDTR Report 2012, NRR

  2. Table 13.1.1: Stock and flow of renal transplantation, 1993-2012 Source: 20th MDTR Report 2012, NRR

  3. New patients Functioning graft at 31st Dec 2,000 1,800 1,600 1,400 1,200 No. of patients 1,000 800 600 400 200 0 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.1.1: Stock and flow of renal transplantation, 1993-2012 Source: 20th MDTR Report 2012, NRR

  4. Table 13.1.2: New transplant rate per million population (pmp), 1993-2012 Source: 20th MDTR Report 2012, NRR

  5. Rate, pmp 10 9 8 7 6 New Transplant rate, pmp 5 4 3 2 1 0 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.1.2: New transplant rate, 1993-2012 Source: 20th MDTR Report 2012, NRR

  6. Table 13.1.3: Transplant prevalence rate per million population (pmp), 1993-2012 Source: 20th MDTR Report 2012, NRR

  7. Rate, pmp 70 60 50 40 Transplant Prevalence rate, pmp 30 20 10 0 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.1.3: Transplant prevalence rate, 1993-2012 Source: 20th MDTR Report 2012, NRR

  8. Table 13.2.1: Renal transplant recipients’ characteristics, 1993-2012 Source: 20th MDTR Report 2012, NRR

  9. Table 13.2.2: Primary causes of end stage renal failure, 1993-2012 Source: 20th MDTR Report 2012, NRR

  10. Table 13.3.1: Type of renal transplantation, 1993-2012 Source: 20th MDTR Report 2012, NRR

  11. Table 13.3.2: Place of transplantation, 1993-2012 Source: 20th MDTR Report 2012, NRR

  12. Table 13.4.1: Post-transplant complications, 1993-2012 Source: 20th MDTR Report 2012, NRR

  13. Table 13.4.2: Biochemical data, 2004-2012 Source: 20th MDTR Report 2012, NRR

  14. Table 13.4.3: Transplant patients’ death rate and graft loss, 1993-2012 Source: 20th MDTR Report 2012, NRR

  15. Annual death rate 3.5 3 2.5 Death rate % 2 1.5 1 .5 0 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.4.3(a): Transplant recipient death rate, 1993-2012 Source: 20th MDTR Report 2012, NRR

  16. Annual graft loss rate 4.5 4 3.5 3 2.5 Graft loss rate % 2 1.5 1 .5 0 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.4.3(b): Transplant recipient graft loss rate, 1993-2012 Source: 20th MDTR Report 2012, NRR

  17. Table 13.4.4(a): Causes of death in transplant recipients, 1993-2012 Source: 20th MDTR Report 2012, NRR

  18. Table 13.4.4(b): Causes of graft failure, 1993-2012 Source: 20th MDTR Report 2012, NRR

  19. Table 13.5.1.1: Patient survival, 1993-2012 Source: 20th MDTR Report 2012, NRR

  20. Figure 13.5.1.1: Patient survival, 1993-2012 Source: 20th MDTR Report 2012, NRR

  21. Table 13.5.1.2: Risk factors for transplant patient survival 1993-2012 Source: 20th MDTR Report 2012, NRR

  22. Table 13.5.1.3: Graft survival, 1993-2012 Source: 20th MDTR Report 2012, NRR

  23. Figure 13.5.1.3: Graft survival, 1993-2012 Source: 20th MDTR Report 2012, NRR

  24. Table 13.5.1.4: Risk factors for transplant graft survival 1993-2012 Source: 20th MDTR Report 2012, NRR

  25. Table 13.5.2.1: Unadjusted patient survival by type of transplant, 1993-2012 *n=Number at risk SE=standard error Source: 20th MDTR Report 2012, NRR

  26. Figure 13.5.2.1: Patient survival by type of transplant, 1993-2012 Source: 20th MDTR Report 2012, NRR

  27. Table 13.5.2.2: Graft survival by type of transplant, 1993-2012 *n=Number at risk SE=standard error Source: 20th MDTR Report 2012, NRR

  28. Figure 13.5.2.2: Graft survival by type of transplants, 1993-2012 Source: 20th MDTR Report 2012, NRR

  29. Table 13.5.3.1: Patient survival by year of transplant (Living related transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  30. Figure 13.5.3.1: Patient survival by year of transplant (Living related transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  31. Table13.5.3.2: Graft survival by year of transplant (Living related transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  32. Figure 13.5.3.2: Graft survival by year of transplant (Living related transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  33. Table 13.5.4.1: Patient survival by year of transplant (Commercial cadaver transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  34. Figure 13.5.4.1: Patient survival by year of transplant (Commercial cadaver transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  35. Table 13.5.4.2: Graft survival by year of transplant (Commercial cadaver transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  36. Figure 13.5.4.2: Graft survival by year of transplant (Commercial cadaver transplant, 1993-2012) Source: 20th MDTR Report 2012, NRR

  37. Table 13.6.1: Medication data, 2004-2012 Source: 20th MDTR Report 2012, NRR

  38. CsA Tacrolimus 80 70 60 50 Proportion of patients 40 30 20 10 0 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.6.1(a)(i): Calcineurin inhibitors: Cyclosporin vs Tacrolimus Source: 20th MDTR Report 2012, NRR

  39. Azathioprine Mycophenolic Acid 70 60 50 Proportion of patients 40 30 20 10 0 '04 '05 '06 '07 '08 '09 '10 '11 '12 Year Figure 13.6.1(a)(ii): Antimetabolites: Azathioprine vs Mycophenolic Acid Source: 20th MDTR Report 2012, NRR

  40. Table 13.6.2: Use of anti-hypertensive medications Source: 20th MDTR Report 2012, NRR

  41. Table 13.7.1: Risk factors for IHD in renal transplant recipients at year 2004-2012 **Hypertension: BP systolic > 140 and BP diastolic > 90, or on anti-hypertensive drugs Source: 20th MDTR Report 2012, NRR

  42. Figure 13.7.1(a): Venn diagram for pre and post transplant complications (in %) at year 2004 Source: 20th MDTR Report 2012, NRR

  43. Figure 13.7.1(b): Venn diagram for pre and post transplant complications (in %) at year 2006 Source: 20th MDTR Report 2012, NRR

  44. Figure 13.7.1(c): Venn diagram for pre and post transplant complications (in %) at year 2008 Source: 20th MDTR Report 2012, NRR

  45. Figure 13.7.1(d): Venn diagram for pre and post transplant complications (in %) at year 2010 Source: 20th MDTR Report 2012, NRR

  46. Figure 13.7.1(e): Venn diagram for pre and post transplant complications (in %) at year 2012 Source: 20th MDTR Report 2012, NRR

  47. Table 13.7.2(a): Systolic BP, 2004-2012 Source: 20th MDTR Report 2012, NRR

  48. Systolic BP <120 Systolic BP 120-129 Systolic BP 130-139 Systolic BP 140-159 Systolic BP 160-179 Systolic BP >=180 100 80 60 Percent 40 20 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 Year Figure 13.7.2(a): Systolic BP, 2004-2012 Source: 20th MDTR Report 2012, NRR

  49. Table 13.7.2(b): Diastolic BP, 2004-2012 Source: 20th MDTR Report 2012, NRR

  50. Diastolic BP <80 Diastolic BP <85 Diastolic BP 85-89 Diastolic BP 90-99 Diastolic BP 100-109 Diastolic BP >=110 100 80 60 Percent 40 20 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 Year Figure 13.7.2(b): Diastolic BP, 2004-2012 Source: 20th MDTR Report 2012, NRR

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