'Human genomes' presentation slideshows

What are Math and Computer Science doing in Biology ?

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Genome Rearrangements

Genome Rearrangements. CIS 667 April 13, 2004. Genome Rearrangements. We have seen how differences in genes at the sequence level can be used to infer evolutionary relations among species

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Bioinformatics Methods and Computer Programs for Next-Generation Sequencing Data Analysis

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Querying a Million Genomes in less than a millisecond?

Interpreting the Genome Technology Review 2009 New technologies will soon make it possible to sequence thousands of human genomes. Now comes the hard part: understanding all the data. Querying a Million Genomes in less than a millisecond?. George Varghese (MSR, UCSD)

627 views • 49 slides

Querying a Million Genomes in less than a millisecond?

Interpreting the Genome Technology Review 2009 New technologies will soon make it possible to sequence thousands of human genomes. Now comes the hard part: understanding all the data. Querying a Million Genomes in less than a millisecond?. George Varghese (MSR, UCSD)

605 views • 49 slides

Last lecture summary

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??? ???????. ??????????????? 2001 ? DNA ???? (polymorphism) SNPs, single nucleotide polymorphisms ????????? ??? DNA ??????????????????? ???????????? 300 ????????????? 1000 ?? SNPs ????? 23500 ? 3000 ???? ????????? RNA ????????????. http://www.genome.gov/. Human genome is 3.08 Gb.

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Sequence assembly using paired-end short tags

Sequence assembly using paired-end short tags. Pramila Ariyaratne Genome Institute of Singapore. SOC-FOS-SICS Joint Workshop on Computational Analysis of DNA 13 July 2009. Overview. Genome sequencing

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Basic Bioinformatics

Basic Bioinformatics. As it is applied to the Bacillus megaterium genome . What we are going to talk about. Why we are doing all this DNA sequencing What genes look like and where they are found How we can compare sequences between different species How genes move between species.

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Tools in Human Genomics

Tools in Human Genomics. Brett Bowman March 3 rd , 2013. Summary. Brief Bio Review of Genotyping Technologies SNP-chips (23andMe) Exome Sequencing (In Clinical Use) Whole Genome Sequencing Review of SNP Analysis tools SNP Databases Report Tools OMIM. My (Sort of) Karyotype.

435 views • 26 slides

Personalized Genomics

Personalized Genomics. Genetic testing status and prospects Types of human variation Detection of human genomic variation GWAS limitations Nextgen sequencing Challenges Ethical questions. J.M. Sikela, Ph.D. April 7, 2011. Types of Genetic Testing. Scientific Research

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Using transcriptomics to delineate the status of Millepora species in the Caribbean Sea

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Gene Regulatory Network Inference

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SNPs

SNPs. DNA differs between humans by 0.1%, (1 in 1300 bases) This means that you can map DNA variation to around 10,000,000 sites in the genome Almost all variation is ancient and 90% of SNP variation are constant across all populations

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DNA Sequencing

DNA Sequencing. Determining DNA Sequence. Originally 2 methods were invented around 1976, but only one is widely used: the chain-termination method invented by Fred Sanger.

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Sequencing Technologies and Human Genetic Variation

Sequencing Technologies and Human Genetic Variation. By Alfonso Farrugio , Hieu Nguyen, and Antony Vydrin. Overview. Introduction Simulating genomic variation and sequencing Analyzing and comparing different sequencing technologies Algorithms for detecting human genetic variation.

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Detection of Structural Variants

Detection of Structural Variants. Structural Variants (SVs). ? Variants that c hange the landscape of chromosomes ? Copy-number variations (CNVs) Microscopic Sub-microscopic deletions/insertions/duplications usu. > 1kb, unbalanced rearrangements large-scale CNVs ? 50 kb

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Human Evolution

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Mammalian Sweet Taste Reception : Tas1R2

Mammalian Sweet Taste Reception : Tas1R2. Nadia Moosvi . Background. T1R2 and T1R3 are metabatrophic, glutamate receptor proteins Tas1R2 and Tas1R3 genes confirmed to function in sweet taste reception by knock out experiments Differences in human and mouse/rat sweet taste . Chimpanzee.

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MCN Marchetto et al. Nature 503 , 525-529 (2013) doi:10.1038/nature12686

Species-specific L1 elements are more abundant in chimpanzee genomes than in human genomes, correlating with decreased levels of A3B and PIWIL2. MCN Marchetto et al. Nature 503 , 525-529 (2013) doi:10.1038/nature12686.

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