'Nucleotide excision repair' presentation slideshows

Mechanisms of DNA Damage and Repair

Mechanisms of DNA Damage and Repair. Principles of Molecular Biology. Group Members. Maira Aleem Bilal Naveed Tanzeela Raza Maheen Malik Zaigham Abbas. DNA Structure. DNA = Deoxyribose nucleic acid. Four Nucleotides - A denine , Cytosine , Thymine , or Guanine .

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Allele

Important Genetic Concepts. Gene. Allele. Genotype. Phenotype. Mutation (Chapt. 16). Classification of Mutations. Mechanisms of Mutagenesis. DNA Repair Pathways. Possible Reading Frames for RNA. A Comprehensive Catalogue of Somatic Mutations From a Cancer Genome Nature (December 2009).

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DNA repair by:S.Solali

DNA repair by:S.Solali. Types of DNA Damage. Deamination: (C ? U and A? hypoxanthine) Depurination: purine base (A or G) lost T-T and T-C dimers: bases become cross- linked, T-T more prominent, caused by UV light (UV-C (<280 nm) and UV-B (280-320 nm)

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Chapter 26

Chapter 26. DNA Restructuring: Repair, Recombination, Rearrangement, Amplification. Chapter 26 Outline :. DNA Repair Recombination Gene Rearrangements Gene Amplification. A summary of the major processes in information restructuring:. Endogenous DNA-damaging reactions:.

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DNA repair

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DNA repair

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DNA Mutations and Repair part 2 and 3

DNA Mutations and Repair part 2 and 3. Chapter 18. Mutation Rates and Frequency. 1 to 10 mutations per million gametes. Incidence within a group. Causes of Mutations. Spontaneous. Induced. Spontaneous. Mispairing of bases Changes in chemical structure of DNA. Tautomers.

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ERCC 1 isoform expression and DNA repair in NSCLC

ERCC 1 isoform expression and DNA repair in NSCLC. NEJM 2013;368:1101 Reporter: ??? Supervisor: ??? 2013.06.03. Predictive/Prognostic factors in NSCLC. IALT. RAND OIZE. N=1867 Stage I~III NSCLC Completed resected Optional RT. Primary: OS. Cisplatin-based adjuvant C/T (n=935).

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Biochemistry 441 Lecture 20 Ted Young February 23, 2007

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ERCC 1 isoform expression and DNA repair in NSCLC

ERCC 1 isoform expression and DNA repair in NSCLC. NEJM 2013;368:1101 Reporter: ??? Supervisor: ??? 2013.06.03. Predictive/Prognostic factors in NSCLC. IALT. RAND OIZE. N=1867 Stage I~III NSCLC Completed resected Optional RT. Primary: OS. Cisplatin-based adjuvant C/T (n=935).

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Xeroderma Pigmentosum Nov 21st 2005

Xeroderma Pigmentosum Nov 21st 2005. Diana Mok Kaitlin Myers Thao Nguyen T. Nguyen. Introduction. First described in 1874 by Hebra and Kaposi 1882: the term XP is first used Rare disorder transmitted in an autosomal recessive manner

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DNA Repair Types

DNA Repair Types. Direct repair Alkylguanine transferase Photolyase Excision repair Base excision repair Nucleotide excision repair Mismatch repair Recombination repair. Direct repair: O 6 -alkylguanine DNA alkyltransferase (AGT).

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DNA Mutations and Repair

DNA Mutations and Repair. Chapter 17. Detecting mutations with the AMES test. SUMMARY OF AMES TEST. AMES TEST. Saccharin Aflatoxin. 2-aminofluorene. Aflatoxin B1. DNA Repair: general characteristics. Double stranded DNA Redundancy of pathways. Types of DNA repair. Mismatch repair

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Mutation

Mutation. ??????? ???? ????? ?????? ??????? ?????? ?????. Dr. Parvin Pasalar Tehran University of Medical Sciences. Mutation. Definition: An un- repaired damages to DNA Causes: It may be spontaneous or induced because of different agents Classifications:

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DNA Repair & Recombination

DNA Repair & Recombination. All 3 genomes in plants constantly being damaged by UV and other forms of radiation, chemicals, and other stresses (e.g., oxidative, heat). Some proteins involved in repair also function in recombination

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What is the name of the enzyme that attaches an amino acid to the 3' end of its cognate tRNA ?

Which term describes the three codons (UAG, UAA, and UGA) that do not code for an amino acid and do not have a corresponding tRNA ? 1. Missense codons ? 2. Termination codons 3. Degenerate codons 4. Anticodons .

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DNA Repair Supplement

DNA Repair Supplement. Read and digest please. Things that Damage DNA. Radiation - Cosmic Chemicals - in the environment DNA Replication Accidents Heat (spontaneous chemical alterations). Types of DNA Damage.

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XPF & its Role in Xeroderma P igmentosum

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Depurination

Depurination. Release of adenine or guanine bases. Deamination. Often converts cytosine to uracil. Pyrimidine Dimers. Linkage of adjacent pyrimidine bases. Summary Of DNA Damage. hydrolysis (including depurinations and deaminations) oxidation methylation.

1.94k views • 10 slides