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P16 prb e2f - PowerPoint PPT Presentation

pRB Binds to the E2F Transcription Factor

pRB Binds to the E2F Transcription Factor. G1 Cyclin CDKs Phosphorylate pRB. Sites of RB Missense Mutations in Tumors. B. A. The A and B domain = pocket = where E2F binds. Tumorigenesis in RB Mutant Mice Requires E2F. Yamasaki et al, Nat. Gen. 18:360 (1998). Proliferation Signals.

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P16 prb e2f - PowerPoint PPT Presentation

pRB Binds to the E2F Transcription Factor