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Pk pd relationship - PowerPoint PPT Presentation

The Ideal DMPK Profile versus Lead Optimization

Clinical DMPK Profile. Rationale. High oral bioavailability: Half-life between 12 and 24 hr: Multiple elimination pathways: No reactive metabolites: No human-specific metabolites: No inhibition of CYP450 enzymes: No induction of CYP enzymes:. Low inter-subject variability/ cost of goods

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Pk pd relationship - PowerPoint PPT Presentation

The Ideal DMPK Profile versus Lead Optimization