'Topoisomerase ii' presentation slideshows

Nuclear Imaging of Multidrug Resistance (MDR)

Nuclear Imaging of Multidrug Resistance (MDR). Hee-Seung Bom cnuh.com. Mechanisms of MDR. 1. P-glycoprotein (Pgp) 2. MDR-associated protein (MRP) 3. DNA topoisomerase II 4. Tripeptide GSH 5. Lung resistant related protein (LRP). P-glycoprotein. ATP-dependent 170-180 kDa

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Topoisomerase Type II Structures

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Supercoiling of DNA

Supercoiling of DNA. Topology A. Right handed supercoiling = negative supercoiling (underwinding) B. Left handed supercoiling = positive supercoiling C. Relaxed state is with no bends D. DNA must be constrained: plasmid DNA or by proteins

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Supercoiling of DNA

Supercoiling of DNA. Topology A. Right handed supercoiling = negative supercoiling (underwinding) B. Left handed supercoiling = positive supercoiling C. Relaxed state is with no bends D. DNA must be constrained: plasmid DNA or by proteins

1.02k views • 29 slides

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 7 NUCLEIC ACIDS AS DRUG TARGETS

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 7 NUCLEIC ACIDS AS DRUG TARGETS Part 2: Section 7.3 (Drugs acting on DNA). Contents Part 2: Section 7.3 (Drugs acting on DNA) 3. Drugs acting on DNA 3.1. Intercalating agents - Topoisomerase II (6 slides)

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Antiparallel implied no M obius bands

MATH:7450 (22M:305) Topics in Topology: Scientific and Engineering Applications of Algebraic Topology Nov 8, 2013: DNA Topology Fall 2013 course offered through the University of Iowa Division of Continuing Education Isabel K. Darcy, Department of Mathematics

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MLL Studies at Minot State University

MLL Studies at Minot State University. Progress report for North Dakota INBRE. Projects. MLL translocation mechanism. What is the role of DNA topoisomerase II in MLL translocations? In vitro cleavage assays DNA binding assays (ChIP) Targeting the MLL-fusion messages by RNA interference.

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Podophyllotoxin (L01CB)

Podophyllotoxin (L01CB). Presented by : Mona Ahmed Sherif. Podophyllotoxin. Has been primarily obtained from the American Mayapple ( Podophyllum peltatum ). Recently it has been discovered that a rare Himalayan Mayapple ( Podophyllum hexandrum ) contains it in a much greater quantity.

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TOPOISOMERASE INHIBITORS and ( Multidrug Resistance (MDR PHL 417

TOPOISOMERASE INHIBITORS and ( Multidrug Resistance (MDR PHL 417. Role of Topoisomerases (TOPO) TOPOISOMERASES induce TRANSIENT BREAK in single strand (TOPO I) and double stands (TOPO II) and RESEALING. Topoisomerase I : Swiveling DNA into 2 single strands which is important for

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Model of DNA strand cleavage by topoisomerase I. Formation of the covalent bond involving tyrosine 723 is shown, as are other active site amino acids believed to function in the cleavage process.

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QSAR Studies of 1,5-di(4-amidinophenoxy)pentane and its analogues for their anti-leishmenial activity

Quantitative activity relationship (QSAR) has been carried out in a series of 1,5-di(4-amidino phenoxy)pentane & its analogues against Topoisomerase II inhibitory activities. The 2D QSAR studies activity is negatively influenced by the presence of linker (O or N), contribution of hydrophobicity and substitution on para position contributed in molar refractivity. The best QSAR model with good correlation coefficient (r2 =0.712), of high statistical significance (> 99.9%) well explained the variance in activity.

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Topoisomerase an Ideal Target for Treatment of Cancer

Topoisomerases are class of enzymes that alter the super coiling of double-stranded DNA. (In super coiling the DNA molecule coils up like a telephone cord, which shortens the molecule.) The Topoisomerases act by transiently cutting one or both strands of the DNA. Topoisomerases are enzymes that regulate the over winding or under winding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes over wound ahead of a replication fork. If left unabated, this tension would eventually stop the ability of the enzymes involved in these processes to continue down the DNA strand. Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymes (topoisomerase I and II), which are enzymes that control the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. The present review is an attempt made in the respect of highlighting the some important information of Topoisomerase enzyme and topoisomerase inhibitors and role of topoisomerase in cancer therapy.

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R1-R10 : Dr. Example Research

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R1-R10 : Dr. Example Research

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