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iPRD : Case Studies

iPRD : Case Studies. Dr James Tunstall. Outline. Introduction Case Study 1 : Selenol Project Case Study 2 : DeltaG Nutraceutical Case Study 3 : Joomo Case Study 4 : Coffee Metabolites Case Study 5 : Polymeric drug delivery system. Introduction.

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iPRD : Case Studies

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  1. iPRD : Case Studies Dr James Tunstall

  2. Outline • Introduction • Case Study 1 : Selenol Project • Case Study 2 : DeltaGNutraceutical • Case Study 3 : Joomo • Case Study 4 : Coffee Metabolites • Case Study 5 : Polymeric drug delivery system

  3. Introduction • iPRD : innovative Process Research and Development • Specialise in all aspects of process development ranging from: • Route design • Reaction scaling • Process engineering • Formulation

  4. Selenol Project Background Selenol and diselenides have a wide application in high end electronics and are known to be used in photovoltaic cells found in solar panels. Synthesis of Selenols on scale can be problematic with associated odours, toxicity and the tendency of Selenols to undergo rapid oxidative dimerisation in the presence of O2. Original Process Case Study 1 Number of problems : Poor Yield (40 – 50 %) and subsequent selenium waste. Highly Toxic H2Se byproduct

  5. Case Study 1 New Process The new process produces almost quantitative yield of the desired selenol. Removes the formation of the toxic malodourous H2Se. Intermediate deselenide is a distillable stable liquid; allowing storage. 1. Excellent Yield; 2. Produces no toxic and malodourous H2Se

  6. Case Study 2 TΔS – Nutraceutical Background Product is a high value nutraceuticalin human trials based on the science of ketone-bodies in human nutrition. Ketone-bodies have a key role in nutrition as highly efficient 'brain and muscle food'. TΔS have identified proprietary precursors that, for the first time, enable the amounts of ketones in our bodies to be elevated, bringing a range of benefits. Current Process The original batch process was catalysed by a heterogeneous catalyst for 5 days. Issues : Extended reaction times produced various impurities Scale up with current catalyst loading was prohibitively expensive

  7. Case Study 2 300mm Plug Flow Reactor 300mm Plug Flow Reactor . 300mm Pressure Gauge Port

  8. Case Study 2 Moving to a continuous system : 1. Reduced reactions times from 5 days to 1 h 2. Shorter reaction times produced fewer impurities 3. Reduced catalyst loading required for 50 kg batch - from 12 kg to 100 g of catalyst. Overall this produced significant cost savings by making the process much more efficient. http://www.tdeltas.com/index.htm

  9. Case Study 3 JOOMO : Natural face cream Background Start-up company with an new skincare product required large batch for further trials but no in-house capabilities Original process Initial product formulation led to variance in product homogeneity caused by frothing. http://www.joomo.coop/

  10. Case Study 3 Original formulation New formulation After two week exploratory work to ensure successful manufacture we delivered two 20 kg batches on time and to customer specifications This enabled distribution of free product samples during the Christmas shopping period.

  11. Case Study 4 Coffee Metabolites Study Background We were asked to synthesise a variety of coffee metabolites recently identified in human plasma and urine after consumption of coffee. Summary We produced multigram quantities of these metabolites for use as analytical standards in a food science study. *Barron, D, et al.; Org. Biomol. Chem., 2010, 8, 5199–5211

  12. Case Study 5 Polymeric drug delivery Background We were contracted to synthesise a variety of polymeric backbones for use as novel drug delivery systems. These particular systems have been successful in delivering various drug payloads including chemotherapy treatments. Summary We have successfully scaled the polymer synthesis to produce multigrams of the desired polymer backbone. We are in the process of grafting a fluorescence stains to allow visual monitoring of the polymer during ex vivo studies. Chen, R.; Eccleston, M.;Yuec, Z.; Slater, N.;*, J. Mater. Chem., 2009, 19, 4217–4224

  13. Summary We have a broad skill base ranging from chemical synthesis to process design and engineering. Our facilities allows to produce materials ranging from grams for use as analytical samples up to kilos of material for more extensive testing. Acknowledgements Prof. John Blacker Prof. Philip Kocienski Prof. Frans Muller Dr. John Cooksey Susan Pollard Janet Welch

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