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Chapter 13 Cannabinoids

Chapter 13 Cannabinoids. History of Cannabinoid Use. Poster currently being offered for sale, 2007. Poster advertising the 1936 film Reefer Madness. Book from the 1950s. http://www.ramblehouse.com/DeMexico.htm. http://www.laughparty.com/funny-pictures/Marijuana-1114.jpg.

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Chapter 13 Cannabinoids

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  1. Chapter 13 Cannabinoids

  2. History of Cannabinoid Use Poster currently being offered for sale, 2007 Poster advertising the 1936 film Reefer Madness Book from the 1950s http://www.ramblehouse.com/DeMexico.htm http://www.laughparty.com/funny-pictures/Marijuana-1114.jpg

  3. History of Cannabinoid UseCannabis plant

  4. History of Cannabinoid UseAn 8000-year time line of cannabis use around the world

  5. History of Cannabinoid Use • Marijuana • Sinsemilla • Hashish • Hash oil

  6. Mechanism of Action D9-tetrahydrocannabinol (THC) • Main active ingredient of cannabis plant • cannabinol • cannabidiol

  7. Mechanism of ActionMean time course of plasma THC concentrations

  8. Mechanism of ActionTime course of plasma THC concentrations

  9. Mechanism of ActionAutoradiogram of a horizontal section through a rat brain

  10. Endocannabinoids • Endogenous cannabinoids • Made from arachindoinc acid • Retrograde messenger

  11. Mechanism of ActionRetrograde signaling by endocannabinoids reduces GABAergic inhibition

  12. Acute EffectsBehavioral Four stages of effects: • Buzz • High • Stoned • Come-down

  13. Acute EffectsBehavioral • High doses • Personality changes • Perceptual distortions • Hallucinations • Occasional effects • Anxiety or panic • Paranoia • Delirium

  14. Acute EffectsPhysiological • Increased blood flow to skin • Increased heart rate • Increased hunger (“munchies”)

  15. Acute EffectsCognitive/ Motor • Motor performance • Thinking /Speech • Pain? • Memory

  16. Acute EffectsSelf-administration

  17. Chronic EffectsProbability of initiating marijuana use as a function of age

  18. Chronic EffectsDesensitization of cannabinoid receptors produced by chronic THC exposure

  19. Chronic Effects Physical dependence?

  20. Chronic Effects Behavioral Health

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