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Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells

Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells. Lindsey E. McQuade and Stephen J. Lippard*. Inorg. Chem. 2010, 49, 7464–7471. 時間 : 99/11/29 13:10 地點 : 化學館 317 演講者 : 陳盈源. Biosynthesis of Nitric Oxide.

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Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells

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  1. Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells Lindsey E. McQuade and Stephen J. Lippard* Inorg. Chem. 2010, 49, 7464–7471 時間 : 99/11/29 13:10 地點 : 化學館317 演講者 : 陳盈源

  2. Biosynthesis of Nitric Oxide Figure 1 Biosynthesis of nitric oxide. NOS catalyzes a five-electron oxidation of an amidine nitrogen of L-arginine to generate NO and L-citrulline. L-hydroxyarginine is formed as an intermediate that is tightly bound to the enzyme. Annu. Rev. Biochem. 1994. 63:175-95

  3. Detection Methods • Colorimetry • Chemiluminescence • Electron paramagnetic resonance • Electrochemistry

  4. Chemiluminescence (or Ar) (human arterioles or exhaled breath) Hetrick, E. M.; Schoenfisch, M. H. Annu. Rev. Anal. Chem. 2009, 2, 409–433.

  5. Fluorescence http://pfast.phys.uri.edu/background/background.php#struct

  6. Fluorescent Probes • Polymers • Nanotubes

  7. Polymers (π-conjugated polymer)

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