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Project leader: Dr. Elena Gabriela Ionita Funding: 1410000 lei

EXPLORING GELS CONTAINING CYCLODEXTRINS BY EPR SPECTROSCOPY: STRUCTURES, PROPERTIES, APPLICATIONS PNII- ID-PCE-2011-3-0328 2011-2014. Project leader: Dr. Elena Gabriela Ionita Funding: 1410000 lei. Summary.

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Project leader: Dr. Elena Gabriela Ionita Funding: 1410000 lei

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  1. EXPLORING GELS CONTAINING CYCLODEXTRINS BY EPR SPECTROSCOPY: STRUCTURES, PROPERTIES, APPLICATIONSPNII- ID-PCE-2011-3-0328 2011-2014 Project leader: Dr. Elena Gabriela Ionita Funding: 1410000 lei

  2. Summary This project refers mainly to obtaining and to studying gel systems containing cyclodextrins. Due to water solubility of cyclodextrin and their properties to form inclusion complexes, during this project will be investigated mainly hydrogels containing cyclodextrins. However, organogels will not be excluded from our investigations. The principal tool for investigation of such systems is EPR spectroscopy, but data are completed involving other physico-chemical methods (e.g. ATR-FTIR, fluorescence, UV-Vis spectroscopy, rheometry). The scientific objectives of the project can be summarized as follow: O1) to monitor the synthesis of different types of gels O2) to investigate the aspects related to gel fibres dynamics, using information obtained from analysis of EPR spectra ( this will involved spin labelling of hydrogels based on covalent network) O3) to investigate the encapsulation / release processes O4) to monitor reactions inside the gel systems This project offers the possibility to develop human resources in the institute, as three master students are involved , and also to improve the infrastructure of our laboratory.

  3. Working Team 2012 Adina Rogozea Florenta Savonea Daniel Angelescu Petre Ionita Ioana Maria Turcu (employed by competition, 2012) Mircea Balan Dan Anghel Cornelia Ilie Adriana Baran Working Team 2013 Ioana Maria Turcu Ana Maria Ariciu (employed by competition, 2013) Maria Victoria Neacsu (employed by competition, 2013) Cornelia Ilie Petre Ionita Mircea Balan

  4. Dissemination - Papers Manuscripts submitted 1. I.M. Turcu, V. Dinoiu, T. Zaharescu, C. Ilie , D. Anghel, P. Ionita, G. Ionita, “Antioxidant activity of Rosemary extracts in solution and embedded in polymeric systems” , submitted Central European Journal of Chemistry 2.Marin Micutz,, Erez Matalon, Teodora Staicu, Daniel Angelescu, Adina Rogozea, Ana Maria Ariciu, Ioana Maria Turcu, Gabriela Ionita , “Hydroxy propyl β-cyclodextrin influences the micellar to gel transition in F127 solutions: a study at macro and nanoscale level “, Macromolecules Manuscripts under preparation The manuscripts under preparation regard : 1. Gel perrmeability of covalent gels determined by spin probe method 2. Investigations on the 12-hydroxystearic acid-based organogels: the effect of metalic nanoparticles and non-gelator species on gel properties 3. Study on albumin/ ligands bearing long alkyl chains complexes; influence of temperature and cyclodextrins Published 1. M. Vasilescu,E. Pincu,V. Meltzer, G. Ionita “Modulation of dansyl moiety fluorescence in systems containing cyclodextrins”, New J. Chem., 2012, 36, 2128–2134 2. Adina ROGOZEA, Florenta SAVONEA, Gabriela IONIŢĂ „EPR study on organogels based on 12-hydroxystearic acid” Rev. Roum Chim., 2012, 57 (7-8), 693-698 3. Rogozea, A.Matei, I. Turcu , G. Ionita, V. Em Sahini,  A.Salifoglou“EPR and circular dichroism solution studies on the interactions of bovine serum albumin with ionic surfactants and β-cyclodextrin”Journal of Physical Chemistry B, 2012, Volume 116, Issue 49, 13 14245-14253 Accepted Manuscript G. Ionita, A.M. Ariciu, I.M Turcu, V. Chechik, “Properties of polyethylene glycol/cyclodextrin hydrogels revealed by spin probe and spin labelling methods”, Soft Matter DOI:10.1039/C3SM52004H

  5. Dissemination - Conference presentations 2012 • Ionita Elena Gabriela Victor Chechik “Investigating cyclodextrin/ PEG hydrogels properties with spin probes” The 45th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry, University of Manchester 25th - 29th March 2012, oral presentation • A. Rogozea, I. M. Turcu, D. Angelescu, G. Ionita “Exploring Pluronic F127/cyclodextrin systems using EPR and fluorescence probe methods”, The 45th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry, University of Manchester 25th - 29th March 2012 poster presentation • Gabriela Ionita, Erez Matalon, Daniella Goldfarb “Exploring Pluronic F127/Cyclodextrin Systems Using Epr Methods”, A XXXII-a CONFERINŢĂ NAŢIONALĂ DE CHIMIE CĂCIULATA, 03-05 octombrie 2012, comunicare orala • Ioana-Maria Turcu, Teodora Staicu, Marian Micutz, Petre Ionita, Adina Rogozea, Cornelia Ilie, Gabriela Ionita “Investigations on the organogels based on 12-hidroxystearic acid. The effect of metalic nanoparticles and non-gelator species on gel properties”, A XXXII-a CONFERINŢĂ NAŢIONALĂ DE CHIMIE CĂCIULATA, 03-05 octombrie 2012, poster • Adina Rogozea, Gabriela Ionita, “An epr spectroscopy study on the interaction of bovine serum albumin with Zn(ll)”, A XXXII-a CONFERINŢĂ NAŢIONALĂ DE CHIMIE CĂCIULATA, 03-05 octombrie 2012, poster

  6. Dissemination - Conference presentations2013 • Gabriela Ionita, “An EPR study on the albumin/surfactant/cyclodextrin systems ”, The 46th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry, University of Warwick 7th - 11th March 2013, oral presentation • M.V.Neacsu, A.M. Ariciu, I.M. Turcu, M. Micutz, T. Staicu, G. Ionita, V. T. Popa, “Changes induced by HPB on pluronic F127 assembly revealed by microcalorimetry and EPR spectroscopy”, ROMPHYSCHEM 15, Bucuresti, 9-11 septembrie 2013, poster • A.M. Ariciu, I.M. Turcu, G. Ionita, “Information on the encapsulation ability of gels derived from spin probe method”,ROMPHYSCHEM 15, Bucuresti, 9-11 septembrie 2013, poster • I.M. Turcu, A.M. Ariciu, C. Munteanu, G. Ionita, “Bovine Serum Albumin induces formation of gold nanoparticles”, ROMPHYSCHEM 15, Bucuresti, 9-11 septembrie 2013, poster • G. Ionita, “Cyclodextrin-ionic surfactants interactions investigated by spin probe method”, ROMPHYSCHEM 15, Bucuresti, 9-11 septembrie 2013, oral presentation • Gabriela IONITA, Ana-Maria ARICIU, Maria Victoria NEACSU, Ioana Maria TURCU, "Spin probes reveal the inhomogeneities at nanoscale level in Pluronic F127 solutions“, "Zilele academice iesene" -Progrese in stiinta compusilor organici macromoleculari., Iasi, 3-5 Octombrie 2013, poster

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