Overview

1. Cancer Centers Program Update and Future DirectionsLinda K. Weiss, PhDDirector, Office of Cancer CentersCancer Center Administrators ForumApril 5, 2011http://cancercenters.cancer.govweissl@mail.nih.gov

2. Overview • Portfolio • FY 2010 Funding, Parent Grant and Special Initiatives • FY 2011 Budget • Organizational Changes • Database, Website, and Centers Report • Miscellaneous Items • Program Announcement 11-005 • Cancer Center Support Grant Guidelines: Where Next?

3. Portfolio • Geographic Distribution of Cancer Centers • 66 Centers in 33/50 states and DC • 40 Comprehensive: 23 states and DC • 26 Cancer Centers: 17 states: 17 states

5. CCSG Funding By Application Type, FY2010, $271,490,840 Total Costs, Parent Grant

6. FY 10 Funding for Special Initiatives • Supplemental Initiatives through OCC: $7.4 M • Ca BIG: 0.8 M • AMC: 1.0 M • CFAR: 1.5 M • NCCCP: 0.8 M • RaPID: 3.0 M • Miscellaneous: 0.6 M • Additional Supplements • CTRP (NCI CCCT): 5.2 M • Core Consolidation (NCRR): 8.0 M

7. FY 2011 Budget • Centers Baseline Budget • Continuing Resolution now in effect until 4/8 • Centers budget has not been finalized • T3/5 funded under NIH policy at 90% • T1/2 budget pending • Anticipated Supplements • Clinical Investigator Team Leadership Award • Clinical Trials Reporting Program • CFAR – CC Pilot Project Awards • AMC – CC Pilot Project Awards

8. Organizational Changes • New NCI Leadership • Dr. Harold Varmus, Director • Dr. Douglas Lowy, Deputy Director • Dr. Peter Greenwald, Associate Director for Prevention and Control • John Czajkowski, Deputy Director for Management • Searches underway • Associate Director for Clinical Research • Director Center for Center for Cancer Genomics • Director for Center for Global Health • Director for Division of Cancer Prevention • Office of Cancer Centers New Staff • Nga Nguyen, Program Analyst • Searches underway • Program Director • IT Database Specialist

9. Database, Website and Centers Report • Summaries • Send as before to ccsgdata@mail.nih.gov • Send content questions to your program director • Website Updates • Send center name, address, directorship changes to your program director • More complex changes will be deferred • Centers Report • Nearing completion • Some information will be web-based (e.g., publications, clinical trials)

10. Miscellaneous Items • Include PMCID numbers with publications list • Large carryover balances are discouraged, particularly as a repeated pattern; there is no guaranteed approval • Fewer administrative supplements (extensions with funds) than in previous years, no ‘recycling’ • New programs and shared resources can’t be established with CCSG funds during non-competing years; realigned programs must be approved by staff

11. Program Announcement 11-005 • Overview Opportunity Announcement • Effective September 25, 2010, NIH required that all mechanisms have a Funding Opportunity Announcement in the NIH Guide for Grants and Contracts • All applications will have to respond to the PAR • The PAR, new Guidelines, and a comparison of 2008 and 2010 Guidelines are on our website.

12. Program Announcement 11-005 • Face page of the application must indicate the PAR # • Resubmission applications (A1) now allowed within 37 months • New page limits for components are in effect • Appendices must be included in the application and can’t exceed 50 pages • Late materials must follow NIH policy – much more stringent limitations • Submission procedures for letter of approval and request for preliminary information have changed

13. Program Announcement 11-005 • Applicants will no longer receive and respond to an administrative review letter • Applicants will no longer submit posters and updated summaries prior to the site visit; information not provided in the original application can be provided at the site visit. • The SRO can no longer selectively accept parts of the application • The application can be returned without review if it doesn’t meet guidelines requirements

14. Program Announcement 11-005 • The 5 review criteria mandated by NIH (significance, investigator, innovation, approach and environment) are now incorporated into the Guidelines. • The 5 criteria will be incorporated into the evaluation of overall center impact but not individual components • Prior to the site visit assigned reviewers will submit criterion scores for the overall application on the 5 NIH mandated criteria. These scores will be in the summary statement, but won’t be discussed at the review. • The 6th year of funding for centers scoring in the outstanding range has been eliminated. • NIH policy and document citations have been updated.

15. The CCSG Guidelines: Where Next? • Major Objectives • Foster collaboration and integration • Facilitate clinical and translational research • Reduce the burden of the application process • Provide new guidance on eligibility and budget requests

16. The CCSG Guidelines: Where Next? • Foster Collaboration and Integration • Recognize research collaborations that extend beyond the walls of the center, including ‘hand-offs’ to other mechanisms or entities that move scientific findings forward • Encourage productive interactions with other NCI and NIH programs • Allow sharing of core services across centers • Eliminate the benchmark ratio

17. The CCSG Guidelines: Where Next? • Facilitate Clinical and Translational Research • Make Clinical Trial and Data Management (the CTO) a separate component and broaden options for support • Harmonize guidelines to recognize leadership and participation in the cooperative groups • Recognize variety and quality in clinical and translational research • Promote team contributions in clinical research

18. The CCSG Guidelines: Where Next? • Reduce the Burden of the Application Process • Eliminate • multiple redundancies across components • detailed capacity and usage tables in shared resource components • data on non-aligned members • requirements for program meeting agendas • Streamline • clinical and other data requirements • requirements for the administrative component

19. The CCSG Guidelines: Where Next? • ProvideNew Guidance on Eligibility and Budget • Raise eligibility minimum, e.g., from $4 to $10 M • Budget Requests • Base request on percent over prior award or a minimum level or ‘floor’ whichever is greater, e.g., • 20% over last T5 award or $2 M DC • Allow for exceptions, e.g., • First T2 • First application after no-cost extension • Major expansion of research • Funding level would still be dependent on merit and NCI budget

20. The CCSG Guidelines: Where Next? • Other Potential Changes • More specificity in language for consortium centers • Expansion/redefinition of staff investigator category • Modification in criteria for Protocol specific resaerch support • Elimination of the limited site visit

21. The CCSG Guidelines: Where Next? • Process • Collaborators/Consultants • NCI • Review • Grants Administration • Senior leadership • Cancer Centers • Approvals • NCI senior leadership • NCAB Subcommittee on Cancer Centers • NIH (to include a new PAR) • Tentative timeline for implementation: 2012

22. QUESTIONS?Questions?