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Trends in Herpes Simples Virus Type 2 infection in the United States — Data from NHANES

Trends in Herpes Simples Virus Type 2 infection in the United States — Data from NHANES. Centers for Disease Control and Prevention (CDC) Emory University Atlanta, USA. NHANES — A Unique Data Source. NHANES — N ational H ealth A nd N utrition E xamination S urvey

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Trends in Herpes Simples Virus Type 2 infection in the United States — Data from NHANES

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  1. Trends in Herpes Simples Virus Type 2 infection in the United States—Data from NHANES Centers for Disease Control and Prevention (CDC) Emory University Atlanta, USA

  2. NHANES —A Unique Data Source • NHANES—National Health And Nutrition Examination Survey • A series of nationally representative surveys of non-institutionalized US population conducted by National Center for Health Statistics, CDC • Survey staff travel across the nation to conduct interviews and health examinations

  3. Statistical Methods • Age-adjustment • US Census as the standard population • Weights • Accounting for oversampling and non-response • SUDAAN software • Accounting for multi-stage sampling design

  4. Laboratory Methods • HSV-2 serology (IgG antibodies) • Type-specific immunodot assay • Glycoprotein of gG2 as antigen • The same assay and the same laboratory were used over time

  5. Tracking HSV-2 Trends Using Data from NHANES • NHANES II: 1976-80 • NHANES III: 1988-1994 • NHANES 1999-2000 • NHANES 2001-2002 (data to be released in May 2004)

  6. NHANES 1976-2000 *Response rate. Remaining sera for all non-whites and a random sample of 20-25% of the whites in each age group were tested.

  7. Changes in HSV-2 Seroprevalence between NHANES II and NHANES III • Overall, 30% increase • The relative increases similar in men (27%) and women (32%) • Relative increases were largest in adolescents.. • Relative increase larger in whites (30%) than blacks (9%)

  8. Changes in HSV-2 Seroprevalence between NHANES II and NHANES III Fleming DT et al. N Engl J Med 1997; 337: 1105-11.

  9. Changes in HSV-2 Seroprevalence between NHANES III and NHANES’99-00

  10. Changes in HSV-2 Seroprevalence between NHANES III and NHANES’99-00 CI, confidence interval. † p<0.05; ‡p<0.001

  11. Changes between NHANES III and NHANES’99-00 in 14-29 year-olds CI, confidence interval. † p<0.05; ‡p<0.001

  12. HSV-2 Seroprevalence in NHANES By Age Group

  13. Conclusions • From the NHANES, HSV-2 seroprevalence increased and then decreased between 1976-2000 • Largest changes occurred in adolescents and in whites • Cohort effect

  14. Discussion • No sexual behavior data in NHANES II • Limited sexual behavior data in NHANES III and NHANES ’99-00 • The number of lifetime sexual partners • Changes in wordings

  15. Teenage Pregnancy Rate in the US, 1972-2000 Rate per 1,000 women aged 15-19

  16. Discussion (cont) • Youth Risk Behavior Surveys (1991-2001)* Ever had sex Had four or more partners Used condoms • Decreased sexual activity accounted for about 25% of the decline in teenage pregnancy between 1988 and 1995 *CDC. MMWR 2002; 51:856-859.

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