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Ecosystem 2

Ecosystem 2. Thresholds. Tiered Interpretation Process. 1. Trigger for further investigation or threshold development Biol responses (incl. mode of action endpoints) or chemistry “free from” objectives 2. Regulatory/management threshold development Mode of action (MOA) based.

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Ecosystem 2

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  1. Ecosystem 2 Thresholds

  2. Tiered Interpretation Process • 1. Trigger for further investigation or threshold development • Biol responses (incl. mode of action endpoints) • or chemistry • “free from” objectives • 2. Regulatory/management threshold development • Mode of action (MOA) based

  3. Definitions/uses • Trigger • Follow up monitoring • Biol verification • Threshold development priorities • Control actions • Threshold • Impairment designation • Reg. or Management action

  4. Threshold Development CEC from Trigger Dose/response data compilation or generation Determine MOA Distribution of effects relative to dose Sensitive Receptor Organisms Conceptual Model Threshold -Action -Impairment -WQO

  5. Potential Triggers • Chemical • Trend • Present at active concentrations (single chem/TEQ) • Biological effect verified • Action by other agencies/EU • Biological • Exposure evident (MOA endpoints/biomarker) • Tissue response • Organism response • Population response (too late!)

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