Case Study-Xylitol

1. Case Study-Xylitol

3. Result Book • Nelson Textbook of Pediatrics, 2007 18e. • possible sources of evidences 2004-2006 Review • Dental caries. Lancet 369:51-9 2007 • Infect Dis Clin North Am 2007; 21(2): 471-502 • possible sources of evidences 2006-2007 Patient Education • Early childhood caries, • Dental cavities, Radiography, Dental

5. Rampant caries (early childhood caries) in 3 yr old child

6. Basic Dental Anatomy

7. Diagnosis (iceberg metaphor)

8. Caries Process

10. Clinical Presentations

11. Clinical Implications

12. Clinical Implications

13. Patient Education

14. 張小妹，六歲，喜歡吃糖但卻滿口蛀口。 Case - Clinician

15. Ask • P: children/adults (with dental caries) • I: chewing gum with xylitol • C: chewing gum without xylitol • O: incidence of dental decay • Type of Question: therapy • Keyword: • Dental caries • xylitol

16. Acquire / Search 2007

17. Search - xylitol dental caries 2009

18. Acquire / Search xylitol dental caries 2007 2009 xylitol 2009

19. Advanced Search - Article Type • Cochrane — thoes found in The Cochrane Database of Systematic Reviews (CDSR) • Trials — Narrows you search to articles containing information about Clinical Trials, Randomized Control Trials, and similar articles.

20. 2005 2005 2004 2007 2008

21. LOE: Level of Evidence (Oxford)

22. LOE (GRADE) • 評分方式：結合研究方法，研究品質，一致性，相關性 • 高（high）= further research is very unlikely to change our confidence in the estimate of effect • 中（moderate）= further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate • 低（low）= further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate • 極低（very low）= any estimate of effect is very uncertain The GRADE Working Group - http://www.gradeworkinggroup.org/

23. Apply ?