1 / 2

RNA-guided Epigenetic Control of Gene Expression

RNA-guided Epigenetic Control of Gene Expression.

shaman
Download Presentation

RNA-guided Epigenetic Control of Gene Expression

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. RNA-guided Epigenetic Control of Gene Expression

  2. As little as 10% of the genome is coding DNA. The rest of the genome is non-coding and is comprised of a diverse family of repeating sequences (e.g. cen, mat, IES). These DNA repeats are foci for the generation and accumulation of short heterochromatic RNA (shRNAs). shRNAs are important for the regulation of heterochromatin initiation and formation. Double stranded shRNAs undergo RNAi-like processing involving dicer (dcr), RdRp (RNA dependent RNA polymerase), argonaute (ago) and Twi1 (piwi-related gene of the argonaute family). The processed shRNA is thought to interact with Chromo domain containing proteins (e.g. Chp1, Pdd1). The resultant complex is the molecular link between DNA target sequence (through pairing with the shRNA), HP1 (Heterchromatin Protein 1), histone H3 methylation and DNA methylation. (Black: genomic region. Purple: DNA repeats. Green: a gene or transcription unit (green). Blue: Promoter-driven mRNA. Dashed blue: intergenic transcription.) Adapted from Jenuwein T. Science 297:2215, 2002. RNA-guided Epigenetic Control of Gene Expression

More Related