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Phase 2

Phase 2. Treatment Experienced (with Sofosbuvir and Ribavirin). Retreatment of Sofosbuvir + Ribavirin Failure with Sofosbuvir-Containing Regimens in Patients with Genotype 2 or 3 . Esteban R, et al . 49 th EASL; April 2014. Abstract 08.

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Phase 2

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  1. Phase 2 TreatmentExperienced (with Sofosbuvir and Ribavirin) Retreatment of Sofosbuvir + Ribavirin Failure with Sofosbuvir-Containing Regimens in Patients with Genotype 2or 3 Esteban R, et al. 49thEASL; April 2014. Abstract 08.

  2. Retreatment of SOF + RBV Failure with SOF-Containing Regimens in GT 2 or 3Study Features Source: Esteban R, et al. 49th EASL; April 2014. Abstract 08.

  3. Retreatment of SOF + RBV Failure with SOF-Containing Regimens in GT 2 or 3Baseline Characteristics Source: Esteban R, et al. 49th EASL; April 2014. Abstract 08.

  4. Retreatment of SOF + RBV Failure with SOF-Containing Regimens in GT 2 or 3Study Design Week 0 12 24 36 GT2 or GT3 Sofosbuvir + PEG + RBV N = 34 SVR12 Sofosbuvir + RBV N = 73 SVR12 Drug DosingSofosbuvir: 400 mg once dailyPeginterferon alfa-2a: 180 µg once weeklyWeight-based Ribavirin (in 2 divided doses): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Esteban R, et al. 49th EASL; April 2014. Abstract 08.

  5. Retreatment of SOF + RBV Failure with SOF-Containing Regimens in GT 2 or 3Results, by Genotype SVR12 by Regimen and HCV Genotype 24/26 25/40 4/4 1/2 20/22 24/38 Source: Esteban R, et al. 49th EASL; April 2014. Abstract 08.

  6. Retreatment of SOF + RBV Failure with SOF-Containing Regimens in GT 2 or 3Results, by Genotype SVR12 by Regimen and HCV Genotype 4/4 1/2 20/22 24/38 Source: Esteban R, et al. 49th EASL; April 2014. Abstract 08.

  7. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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