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SansView Informs Origin of Strain-Hardening in Blood Clots

2D Scattering. 2D Fit. SansView Informs Origin of Strain-Hardening in Blood Clots. Brent T. Fultz, California Institute of Technology, DMR 0520547. Katie M. Weigandt 1 , Lionel Porcar 2,3 , Danilo C. Pozzo 1.

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SansView Informs Origin of Strain-Hardening in Blood Clots

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  1. 2D Scattering 2D Fit SansView Informs Origin of Strain-Hardening in Blood Clots Brent T. Fultz, California Institute of Technology, DMR 0520547 Katie M. Weigandt1, Lionel Porcar2,3, Danilo C. Pozzo1 1Universtiy of Washington, 2Institut Laue Langevin, 3University of Delaware Fibrin is the component responsible for the fascinating, but poorly understood, non-linear mechanical properties of blood clots. Upon tissue injury, fibrin self-assembles into a 3D fibrillarnetwork providing a highly elastic yet strain hardening protective barrier. 0% Strain Until now, utilizing traditional 1D analysis tools, it has been impossible to quantify the structural parameters from SAS measurements of partially oriented objects. Strain Direction 170% Strain Using SansView’s unique ability to properly fit full 2D data sets with non-azimuthally symmetric orientational distributions, these researchers unambiguously demonstrate that the high strain hardening regime is perfectly correlated with a strong alignment of the fibers and a decrease in fibril diameter in accord with one of the competing theoriesand providing critical insights into the strain hardening mechanism Katie M. Weigandt, Lionel Porcar, Danilo C. Pozzo, Soft Matter (in press)

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