1 / 14

Background

sharla
Download Presentation

Background

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Zampelas A, Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C. Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study.Am J Clin Nutr. 2004;80:862-7.De Bacquer D, Clays E, Delanghe J, De Backer G. Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation.Atherosclerosis. 2006;189:428-35.

  2. Background • Inflammation is important to the development of cardiovascular disease (CVD). The effect of coffee consumption on the cardiovascular system is conflicting. • Tea consumption has been inversely related to the risk ofCVD. In vitro and animal model studies suggest an anti-oxidative and/or anti-inflammatory role of tea.

  3. Background - Acute phase response Mononuclear cell Site of injury NO IL-1 IL-1 TNF TNF Tissue oedema Stromal cell TNF Pain Redness IL-1 Inappetite Depression IFNγ IL-6 Local response Liver Fever Acute phase proteins (APPs) production Haematological changes ↑ Cortisol Systemic inflammatory response

  4. Coffee drinking • Design: 1514 men and 1528 women. No history of CVD. Blood consentrations of APPs. • Results:Coffee drinkers (>200 ml/d) vs. nondrin. • C-reactive protein (CRP)higher (p<0.05) • serum amyloid-A (SAA) higher (p<0.05) • The findings were significant after control of age, sex, smoking, body massindex, physical activity status, and other covariates • Conclusions: A relation exists between moderate-to-high coffee consumption and increased inflammation process. This relation could explain, the effect of increased coffee intake on the CVD

  5. Tea drinking • Design: 1031 healthy men in a larger cross-sectional study. Blood APPs concentrations. • Results: Tea drinkers were less obese, smoked less and drank less alcohol and coffee. • CRP, SAA and haptoglobin were significantly negatively associated with tea consumption. • Multivariate analysis did confirm the independence of the observed beneficial role of tea drinking. • Coffee drinking unrelated to inflammation. • Conclusion: Tea drinking might be of interest in reducing the inflammatory process underlying cardiovascular disease.

  6. Casual diagram APP Conc. Coffee CVD risk + CVD risk factors – confounders e.g. BMI, sex, smoking etc. Inflammatory stimulus - CVD risk APP Conc. Tea

  7. Bovine respiratory disease complex - BRD • BRD is a multifactorial disease complex, caused by a variety of etiological agents which acts synergistically (viruses, bacteria, mycoplasmas). • Environmental and husbandry factors as well as impaired resistance of calves to infections are involved as predisposing factors

  8. APPs in cattle Serum amyloid A (SAA) Haptoglobin AGP Albumin

  9. Material and methods • Serum samples (40 rearing units, 10 calves from unit = 400 calves) – SAA conc., viral antibodis. • 1. sampling (acute BRD) • 2. sampling (after 3-4 week, more chronic BRD) • Clinical inves., tracheobronchial lavage, weightgain between samplings • Linear mixed models (unit and sampling time as random factors), SAA log. transformation, age and clinical status of calves controlled in models

  10. SAA association to weightgain (2. sampling) Mean weight gain between to samplings 0.806 (+/- 0.336) kg

  11. Farm factors effect toSAA concentrationsduring BRD(1. sampling)

  12. Farm factors effect toSAA concentrationsduring BRD(2. sampling)

  13. Farm factors effect toSAA concentrationsduring BRD(both samplings)

  14. Casual diagram Confounders e.g. Age of calves, clinical disease, season etc. Effect of BRD to production Respiratory infections Farm factors SAA Conc.

More Related