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PREPARATION OF ACIDS

PREPARATION OF ACIDS. CARBONYLATION OF ORGANOMETALLICS. Hydrolysis of RCN. RCOO-. - NH 3 (smell). RCOOH. (no smell ). EXAMPLE. a-hydroxy acid. CO2. a -hydroxy acid. REACTION OF ACIDS. NUCLEOPHILIC ACYL SUBSTITUTION. Have not we seen this before?. Boring, boring, boring.

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PREPARATION OF ACIDS

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  1. PREPARATION OF ACIDS CARBONYLATION OF ORGANOMETALLICS

  2. Hydrolysis of RCN RCOO- - NH3 (smell) RCOOH (no smell)

  3. EXAMPLE a-hydroxy acid CO2 a-hydroxy acid

  4. REACTION OF ACIDS NUCLEOPHILIC ACYL SUBSTITUTION Have not we seen this before? Boring, boring, boring. Please, no more!!! Give me Cell Bio, Genetics or even Physics, but no more this!!!

  5. Acid Derivatives acetamide

  6. Fisher Esterification H+ + HOH ALCOHOL ACID ESTER NOTE: IT IS AN EQUILIBRIUM REACTION USE BENZENE AS SOLVENT AND STEAM DISTILLED THE WATER FORMED OR USE LARGE EXCESS OF ALCOHOL

  7. Prelude to Fisher Mechanism Where does O18 end up in products? IF IN ESTER, THEN CLEAVAGE OCCURRED AT O18-H IF IN WATER, THE CLEAVAGE AT CARBONYL - O-18

  8. PRIME EXAMPLE OF ACID CATALYZED ACYL NUCLEOPHILIC SUBSTITUTION -HO18H

  9. EMIL FISHER SECOND CHEMIST TO RECEIVE NOBEL PRIZE RANKED AMONG TOP 10 SCIENTIST OF ALL TIMES

  10. CONVERSIONS OF ACIDS TO ACID CHLORIDES Cl atom is easily eliminated in nucleophlic acyl substitutions CAN CONVERT TO ALL OTHER ACID DERIVATIVES AT ROOM TEMPERATURE

  11. EXAMPLES RNH2 R2NH

  12. ESTERIFICATION USING CH2N2 - N2 CONVERTS HIGHER-BOILING ACIDS TO LOWER BOILING ALDEHYDES - GC/MS

  13. CLA (conjugated linoleic acid) - health-giving properties +

  14. REDUCTION OF ACIDLAH

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