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Xbira 250 mg Tablet (Abiraterone acetate)

Xbira 250 mg Tablet (Abiraterone acetate) is an anticancer drug used in men along with another drug called prednisone for the treatment of prostate cancer that has spread to other parts of the body @ Apple pharmaceuticals

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Xbira 250 mg Tablet (Abiraterone acetate)

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  1. Xbira 250mg Abiraterone is sold under brand name Xbira 250mg, the main ingredient which is used as abiraterone . Xbira 250mg is belongs to type of anti-cancer medicationthat will act by decline the androgen production in the body. Androgen is a male hormone that canmaintance the tumor cell in prostate glands. Actually this drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone. DOSAGE The prescribed dose ofXbira 250mg is initial as 4 tablets given orally once daily. The drug Xbira administrated combinationwith 5mg prednisolone twice daily in empty stomach. Xbira 250mg Tablets given on an empty stomach. Foodshould not be taken for at least 2 hours before and at least 1 hour

  2. after the dose of Xbira 250mg Tablets is taken. Swallowedwhole with water. Chew the tablets or Do not crush MECHANISM OF ACTION Androgens are balancethe production of malignant in prostate. Xbira 250mg (abiraterone acetate) is belongs to anti androgen drugs, thatcauses to suppress the enzyme 17α-hydroxylase C 17, 20- lyase (CYP17), it is involves in androgen conglomerate. Reduce the serum testosterone level. Declined the tumor cell occurred. PHARMACOKINETICS Absorption: Time to maximum plasma concentration of Xbira 250mg tablet takes 12 hours. Distribution: Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.

  3. Metabolism: Themain two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate. Excretion: The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Xbira 250mg is 12 ± 5 hours. SIDE EFFECTS Common effects : Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency,Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort General Disorder:Oedema

  4. Cardiac disorders:Hot flush, hypertension, arrhythmias, chest pain, cardiac failure GIT disorders:Diarrhea, dyspepsia Infections and Infestation:UTI Pulmonary disorder:Cough Renal:Urinary frequency, nocturia Injuries:Fractures STORAGE The drug stored at 15℃-30℃ Keep the drug in dry place.

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