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Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy-

Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy- methylase (folate dependent) Glycine. Presynapse Serine

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Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy-

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  1. Glycine Free Amino Acid or Integrated into Proteins Precursor: Serine Serine hydroxy- methylase (folate dependent) Glycine

  2. Presynapse Serine Glycine (sotrage ???) ------------------------------------------------------------------------ Synaptic cleftNa-dependent transporter ------------------------------------------------------------------------ Glycine A-receptor Postsynapse ionotropic Cl- channel, inhibitory Glycine B-receptor = Gly binding site of the NMDA receptor

  3. Release inhibitor: Tetanus toxin Agonists at the Gly A-R Gly, beta-alanine, taurine Antagonists strychnine picrotoxin (Cl- channel blocker)

  4. Agonists at the Gly B-R = Gly binding site of NMDA-R Gly, D-serine, HA 966 Gly transporter inhibitors Under development Antagonists Dichlorokynurenate MNQX

  5. Physiology Gly A-R Presynaptic inhibition: Spinal cord: Feed-back-inhibition of motoneuron activity Gating Habituation Inhibitory on brain stem activity on ARAS In the retina Pathophysiology Reduced activity: muscular convulsions (for example strychnin poisening) Enhanced activity: inhibition of motoneurons inhibition of ARAS (narcosis)

  6. Glycinerig Renshaw neuron

  7. Anatomy Glycin-A-receptor Spinal cord: Renshaw-inhibition (only in vertebrates) Supraspinal: brain stem retina Glycin-B-receptor Corresponds to the distribution of NMDA-receptors

  8. Physiology of Gly B-Receptor Allosteric modulation of the NMDA receptor Pathophysiology Enhanced activity: Enhances affinity for Glutamate and channel opening frequency. Facilitates learning Anti-schizophrenic ??? Reduced activity: Some simailarities with weak NMDA-R-antagonists Psycic and motor activation (in Alzheimer‘s disease Gly-R density is reduced)

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