By: Jane Xu and Alexandrea Gosnell 7-5

1. By: Jane Xu and Alexandrea Gosnell 7-5

2. What is CF? Cystic Fibrosis is an inherited disease. It causes thick mucus to get stuck in your lungs causing lung disease. This disorder can kill you.

3. Some Symptoms Include… • Excessive coughing • Wheezing • Bronchitis • Chronic sinusitis • Asthma • Salty sweat/skin • Clubbed fingers (deformed) • And more Symptoms vary from patient to patient.

4. Cystic Fibrosis is caused by a mutation in the gene of Chromosome 7, so it is not a sex-linked disorder. • There are more than 1,000 mutations including salty skin, lung infections and more deformities. • It contains the information for the cystic fibrosis transmembrane conductive regulator gene (CFTR). that can cause CF. • The CF is recessive allele. The Genetic Cause These are all of the normal chromosomes found in humans.

5. Stats… 1 in 29 Caucasian people have Cystic Fibrosis. 1 in 46 Latino people have Cystic Fibrosis. 1 in 65 African American people have Cystic Fibrosis. 1-in-90 for Asian-Americans have Cystic Fibrosis.

6. The Life Expectancy Of A Person with Cystic Fibrosis • The life expectancy of a person with Cystic Fibrosis I about 37.4 years old as of 2008. • A person in 1959 with CF was only supposed to live until they were 6 months old. • In 1980s they were expected to live until they were 14 years old. • Ten years ago they were expected to live until they were around 18 years old. • The median life expectancy of infants around 1970s was age of 4. The life expectancy has increased due to more tests and better research. Scientists know more about why it occurs and how to manage it.

7. More tests and accuracy have been discovered making it easier to identify the disease. • There are about 1,000 new cases each year. • 70% of all people with cystic .fibrosis are diagnosed by the age of two. • 45% of the patient population is age 18 or older. These pictures show two girls with Cystic Fibrosis. The mask helps them breathe with the condition.

8. Parents Mother- Carrier Father- does not have Cystic Fibrosis Punnet Squares C c C Parents Mother- Carrier Father- has Cystic Fibrosis C ½ chance of having an unaffected carrier ½ chance of having an affected child C c c c ½ chance of having an unaffected carrier ½ chance of having an affected child

9. Parents Mother-carrier Father- carrier Punnet Squares cont… C c C Parents Mother-has Cystic Fibrosis Father- has Cystic Fibrosis c ¼ chance of having a normal child ½ chance of having a carrier of CF ¼ chance of having a child with Cystic Fibrosis c c c c All children would have CF

10. This picture shows how if you only have one faulty CFTR gene you become a carrier and if you have 2 faulty genes you will have cystic fibrosis.

11. Tested and Diagnosed • CF is most often diagnosed by a sweat test which measure the amount of salt in their sweat. A reading of more than 60 mmol(millimoles) of salt means that the person has two CFTR genes. • Genetic testing can also diagnose this condition. This shows the mutation in Chromosome 7 versus the normal chromosome 7. This is a picture of the digital chloridometer the machine used to measure the amount of salt in your sweat.. This person does not have the cystic fibrosis gene.

12. This picture shows how some of the organs can be affected by Cystic Fibrosis.

13. Some Famous People With Cystic Fibrosis Include… • Gregory Lemarchal (musical artist) • Bob Flanagan (musical artist) • Alice Martineau (musical artist) • Laura Rothenbourg (author)

14. Alexandra Deford (daughter of Frank Deford, sports writer). Fraser Brown (son of UK’s Prime Minster, Gordon Brown Even Albert Einstein was thought to have Cystic Fibrosis.

15. The End.