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Structure Investigation of Fam20C, A Golgi Casein Kinase

Structure Investigation of Fam20C, A Golgi Casein Kinase. Sharon Grubner National Taiwan University Seventh Weekly report – August 7 th , 2013. Progress. FTProd

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Structure Investigation of Fam20C, A Golgi Casein Kinase

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  1. Structure Investigation of Fam20C, A Golgi Casein Kinase Sharon Grubner National Taiwan University Seventh Weekly report – August 7th, 2013

  2. Progress • FTProd • Uploaded all output pdb files from FTMap together to VMD, aligned and analyzed them using the plugin FTProd in order to find ‘consensus’ sites on Fam20C surface • Read papers about electrostatics in context of drug discovery • VolMap • Using VMD plug-in VolMap, found that there is water present in the ADP binding pocket ~65% of the simulation time. • Continued qualitative analysis • My progress is being updated on a daily basis and shared with my mentors on Evernote.

  3. FTProd

  4. Goals for Next Week • FTProd • Confirm my ‘consensus’ sites analysis with my mentors and repeat some aspects of the analysis if necessary • VolMap • Confirm my water occupancy results with my mentors and continue analysis • Learn about enthalpy-entropy compensation and use that information to analyze the movement of Fam20C ‘hinge’ residues • Continue qualitative analysis

  5. Culture Shilin night market

  6. Acknowledgments • UCSD (University of California San Diego) • Dr. Gabriele Wienhausen • Dr. Peter Arzberger • Dr. RommieAmaro • Teri Simas • NTU (National Taiwan University) • Dr. Jung-HsinLin • Julia Brown Research Scholarship

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