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Hydrogels / Applications in Opthamology

Hydrogels / Applications in Opthamology . Polyelectrolyte Hydrogels. Hydrophilic polymer chains containing positive or negatively charged functional groups that interact electrostatic interactions to form a cross-linked network that attracts water. Hylauronic Acid. Polyelectrolyte Multilayers.

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Hydrogels / Applications in Opthamology

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  1. Hydrogels /Applications in Opthamology

  2. Polyelectrolyte Hydrogels Hydrophilic polymer chains containing positive or negatively charged functional groups that interact electrostatic interactions to form a cross-linked network that attracts water

  3. Hylauronic Acid

  4. Polyelectrolyte Multilayers Layer by layer deposition

  5. Alginate gels

  6. Enzyme Immobilization

  7. Cell Encapsulation

  8. Alginate gels

  9. Alginate gels

  10. Applications • artificial tendon and cartilage • wound healing dressings (Vigilon®, Hydron®, • Gelperm®) • non-antigenic, flexible wound cover • permeable to water and metabolites • low-strength • artificial kidney membranes • artificial skin • maxillofacial and sexual organ reconstruction materials • vocal cord replacement

  11. Hydrogels: Applications Earliest biomedical application contact lenses • good mechanical stability • favorable refractive index • high oxygen permeability • needs hygienic maintenance • unable to correct for astigmatism

  12. Acrylates

  13. Methacrylates

  14. Poly(methyl methacrylate)

  15. Poly(2-hydroxyethylmethacrylatepHEMA

  16. Hydrogels: PHEMA • The most widely used hydrogel • water content similar to living tissues • inert to biological processes • shows resistance to degradation • permeable to metabolites • not absorbed by the body • withstands sterilization by heat • prepared in various shaped and forms

  17. Contact lens • PMMA • HEMA • Fabrication methods • Computer assisted cutting (lathe)-PMMA rods • Spin casting-polymerization • Molding-polymerization

  18. Intraocular lens • PMMA • HEMA • Polymer backbone - mixture of PMMA and PHEMA • Varying water contents • Additives such as UV blockers

  19. Foldable IOL complications/explantations -

  20. Reasons for Revision Surgery • Incorrect lens power seen most commonly • Glare/optical aberrations • Dislocation/decentration • Late postoperative opacification

  21. IOL Optic Opacification • Surface opacification • Opacification within the substance of the optic • Analysis of opacifications reveals presence of calcium • Calcium staining • Scanning electron microscopic analysis

  22. Accommodative IOL: 1CU (HumanOptics) Total diameter: 9.7 mm

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