Joan Boegel Associate Director, Environmental Affairs Genzyme Corporation March 18, 2005

1. The Evolving Role of the Environmental Manager at Genzyme Corporationfrom Compliance to Sustainability Joan Boegel Associate Director, Environmental Affairs Genzyme Corporation March 18, 2005

2. Outline • About Genzyme • Environmental Department • Changes since 2000 • Business Tools for Environmental Management • Key Priorities • Future Opportunities

3. Genzyme Corporation • One of the world’s foremost biotechnology companies • Founded in Boston in 1981 • Dedicated to making positive impact on lives of patients with serious diseases • Products and Services focused on • Rare inherited diseases • Kidney disease • Orthopedics • Transplant / immune diseases • Cancer • Genetics / Diagnostics

4. Genzyme - Global and Growing • 7,000 employees in 29 countries (Up from 4,434 in 2000) • Serving patients in more than 80 countries • 14 manufacturing sites • 9 genetic testing lab sites • More than 25 marketed products and services • 2004 revenues of $2.2 billion (Up from $0.9 billion in 2000)

5. Genzyme’s Corporate Environmental Commitment “Genzyme Corporation will conduct its businesses in a safe andenvironmentally responsible manner in compliance with all health, safety and environmental regulations. Genzyme will operate its facilities so as toprotect our environment and conserve our natural resources, making our corporate and residential neighbors proud to have Genzyme in their communities. Genzyme managers will provide leadership to achieve these goals through their plans and operations and all employees will incorporate these goals and practices into their daily operations." Henri A. Termeer President and CEO

6. Genzyme CenterCambridge, MA • Green Building symbolic of Genzyme’s commitment to the environment, the community and employees • Reflective of Genzyme’s core values • Environmentally responsible and energy-efficient INNOVATION COLLABORATION TRANSPARENCY

7. Genzyme’s Environmental Department Our mission is to ensure compliance with environmental regulations and to promote pollution prevention and environmental stewardship at Genzyme facilities worldwide.

8. Organization Structure HSE Sr. Steering Committee Outside MA Site Environmental Professionals

9. Genzyme - Massachusetts • 14 Sites in Cambridge, Allston, Framingham & Westborough • Manufacturing – 6 sites Therapeutics, Diagnostics, BioSurgery • Research – 4 Genzyme Science laboratory buildings • QC Laboratories • Clinical Laboratory – Genzyme Genetics • 4 Office-only buildings • 1.5 million sq. ft. • >3,000 employees

10. GENZYME Growth – Acquisitions New facility construction / renovation Old facility shutdown / closure / moves New processes and operations New employees EXTERNAL Changes since 2000 New Environmental Compliance Requirements More information available on-line More electronic reporting Environmental Agency (DEP, MWRA) staff and budget cuts Business Trends – Environmental Management Systems, Sustainability

11. Changes since 2000 • Introduction of GEMS – Genzyme Environmental Management System • Construction and opening of Genzyme Center – Green Building • Expansion of “Beyond Compliance” initiatives– recycling, stewardship events, paper use reduction

12. Impact • Workload growing • Scope & variety of job expanding It’s not just about COMPLIANCE any more. • Management and employee involvement • Recognition / Awards Genzyme Center EPA WasteWise EPA Best Workplaces for Commuters Dow Jones Sustainability Index

13. Genzyme Environmental Management System GEMS is: A cycle of planning, implementing, reviewing and improving the actions that Genzyme takes to address its impacts on the environment. • Modeled on ISO 14001 • Supported by senior management • Flexible and integrated into each site’s operations Goals • Compliance with applicable regulations • Continual improvement of Genzyme’s environmental performance

14. GEMS - Business Tools for Environmental Management • POLICY Site Environmental Management Policy • KNOWLEDGE & TRAINING Environmental awareness training • MONITORING & MEASUREMENT Key Environmental Performance Indicators (KEPIs) • INTERNAL COMMUNICATION • Reports – Quarterly & annual • Intranet – Environmental Website

15. Site Environmental Management Policy

16. Environmental Awareness Training Scope – All employees – office, lab, mfg Content • Site Specific • Intro to GEMS, Environmental Dept., compliance requirements, beyond-compliance programs • Links to resources on intranet Delivery • Roll-out by e-mail from Site Management or Committee • Computer-based • Self-guided PowerPoint presentation • On-line survey tool quiz Records • Employee Learning Management System Results • 70% participation by year-end 2004 overall • Strong Site Management or Committee involvement yields best % completion

17. Compliance Air Emissions Energy Use Water Use Solid Waste Chemical Waste Stewardship Monitoring and Measurement of Environmental Performance GEMS identifies seven Key Environmental Performance Indicators (KEPI’s): • These seven indicators are tracked and reported at all Genzyme sites in order to measure our impact on the environment.

18. KEPI Success Stories Measurement & Reporting identifies opportunities for improvement • Water conservation • Landscape irrigation • Autoclave steam condensate quench • Air emissions • Surface disinfection • Solid Waste / Recycling • Better data collection / new recycling programs • Paper Reduction – double-sided printing, paperless meetings

19. Quarterly Environmental Report • Sent to HSE-SSC in advance of their quarterly meeting • Highlights discussed at meeting • Shared with site environmental professionals worldwide • Compliance • Regulatory non-compliance events • Summary of any inspections or audits • Permit activity • Success Stories • Water Conservation, Energy Savings, Waste Reduction, Recycling • Stewardship • Volunteer events – e.g., Charles River clean up • Donations

20. Annual Environmental Performance Reports • Contents • KEPI data & narrative • Progress vs. goals • New goals • Success stories • “Green Initiative” awards • Audience • Genzyme management • Genzyme employees • Functions • Awareness • Comparisons • Goals

21. Intranet Environmental Web Site Navigate to your area of interest.

22. GEMS Benefits • Proactive Environmental Compliance Assurance • Environmental risks, liabilities, and impacts minimized • Reduced waste generation and costs • Reduced energy and water use and costs • Reduced emissions to environment • Positive corporate image with environmental agencies, the public and employees • Recognition as “green” company – biotechnology industry leader • Employee pride in the organization

23. Key Priorities – short term • Environmental Performance Reports • On-line service to access regulations and analysis • Voluntary programs • EPA Labs 21 for Framingham Science Center • EPA / DEP WasteWise at Cambridge, Westborough & Framingham • EPA Performance Track • Paper Use Reduction • Documentation  QA system

24. Future Opportunities • Innovation • Green building • Green power • Green chemistry • Collaboration • Within Genzyme • Peer groups • Agency partnerships • Environmental non-profits • Community • Transparency Sustainability Reporting to Public INNOVATION COLLABORATION TRANSPARENCY