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MCU Overexpression Enhances Mitochondrial Ca2+ Uptake and Sensitizes to Apoptotic Stimuli

Overexpression of MCU increases mitochondrial Ca2+ accumulation and sensitivity to apoptotic triggers. GFP-tagged MCU indicates mitochondrial localization and membrane topology. Study by De Stefani et al. in Nature, 2011.

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MCU Overexpression Enhances Mitochondrial Ca2+ Uptake and Sensitizes to Apoptotic Stimuli

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  1. MCU overexpression increases mitochondrial Ca2 accumulation in intact and permeabilized cells, buffers cytosolic [Ca2] rises, and sensitizes to apoptotic stimuli; GFP-tagged MCU demonstrates mitochondrial localization and indicates a putative membrane topology. D De Stefani et al. Nature000, 1-5 (2011) doi:10.1038/nature10230

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