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Life and Medical Sciences Program

U.S. Department of Energy. Office of Science. Life and Medical Sciences Program. Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house. Genomics: GTL

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Life and Medical Sciences Program

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  1. U.S. Department of Energy Office of Science Life and Medical Sciences Program • Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house. • Genomics: GTL Systems biology research in bioenergy, bioremediation and carbon sequestration; development of bioenergy research centers. • Health Effects Research - Low Dose Radiation Program - Nuclear Medicine - Advanced bio-medical instrumentation - ELSI, Human Subjects Protection Program

  2. Shewenella Federation PNL, ANL,ORNL,USC,UCLA,MSU,BU. OU,MBL,DRI,BIATECH,GEONOMATICA • Comparative genomic and physiological analysis of Shewenella species. • Functional genomics energy flow and electron transport. • Genetic and functional characterization of c-type cytochromes • Characterization and modeling of metabolic and regulatory networks.

  3. Federation Integrated Approachto Shewanella Biology MR-1 Genome Sequence, Bioinformatics Information Synthesis & Interpretation Linked measurements Imaging AFM, EM, CLSM Immuno-EM Computational Biology Concepts & Hypotheses Physiology & Metabolism Cellular networks, Modeling Controlled Cultivation Proteomics MS 2-D gel Data Analysis & Integration • ▲ • Perturbation: • mutation • cultivation Gene Expression Microarrays Reporters

  4. U.S. Department of Energy Office of Science DOE Imaging Instrumentation Clinical PET MicroPET Mobile PET

  5. Awake Animal Project : The Rat CAP U.S. Department of Energy Office of Science • Miniaturized, novel electronics which allows the signals from the RatCAP to be collected, amplified and analyzed • LSO crystal arrays, backed to photodiodes and electronics board. • Image resolution comparable to micro-PET RatCAP MicroPET Schlyer, Vaska, Woody, 2006

  6. Six 16-electrode devices implanted in humans. Longest implant in for 3 years. • 60 electrode device completing pre-clinical testing in dogs. Human study scheduled for 12/06. • Component design for 250 electrode device completed. ORNL, ANL, LANL, SNL, LLNL, BNL, USC, UC SC, CalTech,NC State, Second Sight

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