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What are the greatest challenges facing our region, state, nation, and world? What does it take to address them?

The Challenge. What are the greatest challenges facing our region, state, nation, and world? What does it take to address them? Who can help the majority of global citizens, including those locally and nationally, who lack access to fundamental resources? What is our role? .

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What are the greatest challenges facing our region, state, nation, and world? What does it take to address them?

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  1. The Challenge • What are the greatest challenges facing our region, state, nation, and world? • What does it take to address them? • Who can help the majority of global citizens, including those locally and nationally, who lack access to fundamental resources? • What is our role?

  2. INNOVATION PROCESS

  3. INNOVATION PROCESS

  4. INNOVATION PROCESS

  5. INNOVATION PROCESS

  6. Three Translational Methods • Launch innovators into the world. • Persuade. • Create social and commercial ventures

  7. Five Recommendations

  8. Prepare faculty, graduate and undergraduate students, staff, and the broader Carolina community with the knowledge, skills, and connections necessary to translate new ideas into innovations. • Goal 1.2 Build capacity for innovation. • Action 1.2.1 Provide educational opportunities about innovation. • Build on successful existing programs • The Minor in Entrepreneurship • The Chancellor’s Faculty Entrepreneurship Boot Camp • First Year Seminars • Launching the Venture • Carolina Challenge • Action 1.2.3 Create Student Innovation Hub Example

  9. Collaborate with diverse groups on campus and beyond to explore issues, options, and creative approaches that may lead to innovations. • Goal 2.1 Enhance robust interdisciplinary collaboration • Action 2.1.1 Set as a top priority advancing applied sciences • 5 Applied Sciences Distinguished Professorships • Goal 2.2 Collaborate, coordinate around key themes of local, national, and global significance • Action 2.2.1 Create the Key Themes Initiative Examples

  10. Translate important new ideas more expediently and at an increased volume into innovations that improve society. • Goal 3.1 Advance social entrepreneurship • Action 3.1.1 Refine and develop an integrated campuswide approach • Goal 3.2 Optimize the university’s commercialization output • Action 3.2.1 Expand the Entrepreneurs-In-Residence program • 18 EIRS throughout the campus Examples

  11. Align people, incentives, resources, and processes to strengthen an intentional culture of innovation at Carolina. • Goal 4.2 Recruit, retain, and reward faculty, students, and staff who show promise, aptitude, and/or achievement in innovation • Action 4.2.1 Recruit innovators and future innovators • Action 4.2.2 Reward activities that contribute to the culture of innovation at Carolina • Create two Innovation Professorships • Goal 4.4 Provide funds to support nascent and promising innovations on campus • Action 4.4.1 Establish the Carolina Innovation Fund Examples

  12. Catalyze innovation at Carolina by facilitating the work of faculty, staff, and students as they put important ideas to use for a better world. • Goal 5.1 Leverage the talents of leaders across campus to prepare, collaborate, translate, and align resources and processes to strengthen the culture of innovation at Carolina • Action 5.1.1 Create management groups of program leaders from across the campus • Goal 5.2 Create the Chancellor’s Catalyze Group to facilitate the implementation of this Roadmap • Action 5.5.2 Help raise funds and manage the single source gateway to innovation to ensure faculty, students, and staff are aware of available resources and opportunities for innovation. Examples

  13. Rethinking & New Programs • Career Services: Gary Miller, new title, includes innovation. Now hosting the CSIT meetings, opening an incubator on Hanes fourth floor called H4 for this summer. Working on the Navigating concept using their technology. • Medical School: Appointed Cam Patterson as Associate Dean of Medical Entrepreneurship. Moved TRACS Carolina Kickstart reporting to him. Exploring how the medical and business schools could work together to do innovative work. • Biomedical engineering – Nancy Allbritton, faculty entrepreneur – joint program with NC State. Integrating graduate and undergraduate. Important step for Applied Sciences. • Entrepreneur-in-Residence: Expanding and improving. Regular Meetings.

  14. Rethinking & New Programs • Carolina Kickstart – reinventing itself to better serve startups in the sciences. Building two new funds: Carolina Catalyst (evergreen loan pool, $25K-$75K) and Carolina Capital (seed fund); Carolina Entrepreneur Network of alums. • IAH – new $100,000 award for Faculty Innovation Grants. • Innovation Scholars – first one this year, four more for next year. 4-year full scholarship. • Dean’s Innovation Fund in Journalism from Innovation Circle member. • Campus Y – strategic planning to strengthen it social innovation work. • Buck Goldstein working with IAH to host a series of seminars on the co-authored book with Holden Thorp: Engines of Innovation.

  15. Rethinking & New Programs • Students: CSIT just elected their new leader, Hudson Vincent. Working on Digital Navigator. Student Innovation Fair in April. • Speaker Series: Desh Deshpande, Steve Case, Cheryl Dorsey. Bob Langer MIT • Global Education Center and School of Public Health working on Entrepreneur-in-residence program about big challenges. Water conference huge success. • First Year Seminars: Revupinnovation.com • The Minor in Entrepreneurship in the College of Arts and Sciences, academic committee, getting closer to endowment goal. • University Entrepreneur-in-Residence, received endowment for position. • Grant from Blackstone Charitable Foundation for entrepreneurial development in the Triangle. Brought in Duke, NC State, NC Central, CED as partners.

  16. National CTSA & TraCS Goals To improve how biomedical research is conducted across the country To reduce the time it takes for laboratory discoveries to become treatments for patients To engage communities in clinical research efforts To train the next generation of clinical and translational researchers

  17. About TraCS North Carolina Translational and Clinical Sciences (NC TraCS) Institute Home of the NIH CTSA – Clinical and Translational Sciences Award 1 of 55 CTSA institutions ; 60 total expected Infrastructure grant; Funded May ’08 ~ 260 faculty/staff involved in 15 cores and programs and 59 specific aims, serving over 2,000 members across the state Home on 2nd floor of Brinkhous-Bullitt Bldg.

  18. NC TraCS Activities Throughout North Carolina Counties NC TraCS Activities has spanned across 68 of the 100 NC Counties Javacia C. Jackson

  19. NC TraCS Academic Partners • Academic Partners • Duke University • Durham Technical Community College • East Carolina University • NC Agricultural and Technical University • NC Central University • UNC Charlotte • NC State University • Activities with Partners vary: • Faculty at UNC and partner schools collaborate; partners match $50K program; share resources and educational activities

  20. NC TraCS Community Partners American Indian Mothers, Inc. Area L Health Education Center Carolinas Medical Center Charlotte Area Health Education Center Communities in Schools of Orange County, Inc. Community Care Networks of North Carolina Duke Primary Care Research Network Durham Committee on the Affairs of Black People Durham County Health Department Eastern Carolina Association for Research and Education El Centro Latino Family Support Network of North Carolina GlaxoSmithKline Greensboro Area Health Education Center The Hamner Institute for Health Sciences Healthy Carolinians IBM Levine Children’s Hospital McNeil Consumer Healthcare Mecklenburg Area Partnership for Primary Care Research Mid Carolina Cardiology Moses Cone Health System National Institute of Environmental Health Sciences (NIEHS) New Hanover Medical Center North Carolina Biotechnology Center North Carolina Coalition Against Domestic Violence North Carolina Dept Health & Human Services/Division Public Health North Carolina Family Medicine Research Network North Carolina Healthcare Information and Communications Alliance (NCHICA) North Carolina Institute of Medicine NC Multi Site Adolescent Research Consortium for Health North Carolina Research Campus, Kannapolis, NC Quintiles Transnational Corp. Renaissance Computing Institute (RENCI) Research Triangle Institute Robeson County Primary Care Research Network SAS SouthEast Area Health Education Center Wake Area Health Education Center

  21. SouthEastern CTSA Consortium (SECC) • Eight CTSAs: Duke, Emory, MUSC, UNC, UAB, U Arkansas, U Florida, Vanderbilt • First Meeting early 2010 • Current activity: • Emory, Duke and UNC are moving forward on a project to share electronic medical record data for clinical research; comparative effectiveness research on hypertension across the south east. We intend to seek funding for this project.

  22. TraCS Cores and Programs Biomedical Informatics Biostatistics Clinical & Community Dissemination Community Engagement Commercialization Clinical Data Management Clinical & Translational Research Center Clinical Dental & Inflammation Research Education Governance Grant Proposal Assistance Novel Methodologies Pilot Grant Program Recruitment Regulatory Research Ethics Strategic Opportunities Translational Technologies TraCS Central

  23. TraCS Offers 3 Levels of General Pilot Funding

  24. $100K Planning Grants - Aimed at: Stimulating UNC-CH investigators to serve as PIs for new centers, roadmap initiatives, and multicenter clinical trials. Reducing the barrier for faculty who conceive of large-scale proposals but never move forward because of the daunting process

  25. Projects outside UNC • 17 funded pilot grants have PIs outside UNC, including these academic institutions: • East Carolina University • Elizabeth City State University • North Carolina State University • UNC Charlotte And at community organizations including: • The Hamner Institutes for Health Sciences • Haywood Regional Medical Center • Mecklenburg Area Partnership for Primary Care Research • WakeMed Health and Hospitals

  26. Submitted, Funded Pilot Grants by PI/Co-PI, School

  27. Preliminary Outcomes - TraCS Pilot Program

  28. Examples of how NC TraCS is improving research at UNC-CH • Commercialization – NC KickStart: • Offering assistance to faculty with their commercial start-up ventures, including access to business experts, education, mentoring, and pilot funding • Numerous faculty companies assisted to date • Research Navigation • Four faculty each 49% effort assist investigators develop new ideas or relate a research question to translational medicine and assist in the development of clinical and translational investigator teams

  29. Biomedical Translation Bench Bedside Boardroom Commercialization

  30. University Commercialization Paths Biomedical Innovation Patent Established Company (BigCo) University Startup (NewCo) Product Strategy Business Concept License Management Team Sponsored Research Investment Product Development Product Development Commercial Product

  31. Mission • Increase the impact of biomedical innovations by fostering and promoting entrepreneurial commercialization

  32. Background • Originally formed as NC BioStart • Driven by faculty frustration • Written into CTSA proposal • Aim: Mentor faculty in commercialization efforts • Program expanded in last 1.5 years • Renamed Carolina KickStart • Full-time director • Programs beyond mentoring

  33. Goals of Carolina KickStart • Educate faculty and students as to the process and expectations of commercializing technologies through startups. • Mentor faculty and students during the process of entrepreneurial commercialization. • Connect outside resources and talent (entrepreneurs, advisors, investors, and services providers) with UNC startup opportunities to help facilitate the commercialization process. • Fund technology and venture development by providing internal funding and facilitating external funding (SBIR, investors). • Incubate startup companies by providing suitable space

  34. Personnel • Cam Patterson, MD, MBA Executive Director • Don Rose, PhD Director • Andrew Kant, MS Assistant Director • Justin Brown, PhD Technology Scout • John Strenkowski, MBA Business Fellow • Ricky Spero, PhD Technology Fellow • Joel Shaffer, PhD Entrepreneur-in-Residence • Tom Mercolino, PhD Entrepreneur-in-Residence • Perry Genova, PhD Entrepreneur-in-Residence

  35. Partners

  36. Features of the Program

  37. KickStart Portfolio Companies • Katharos—dialysis device for serum phosphate • NovoLipid—lipid-modified chemotherapy agents • Cortical Metrics —non-invasive brain assessment • Hibernaid—pharmacological hypothermia • Rheomics—mechanical biology micrcoscopy • Cell Microsystem—cell isolation and culture device • Enci Therapeutics —anti-angiogenesis mAb for cancer • NeuroGate—therapeutics for neuropathic pain • KL Medical —minimally invasive portal for heart surgery • Vascular Pharma—mAb for reducing diabetes-induced CHD • G-Zero—therapies for chemo induced immunosuppression • Synereca—co-therapeutics for potentiating antibiotics • Qualiber—liposomal drug delivery platform • Clinical Sensors —NO sensor for early sepsis detection • Ironwood Material Science —materials for dental implants • X-in8—therapeutics to reduce organ transplant rejection

  38. What will Holden release at University Day????? Innovate.unc.edu

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