1 / 14

Infective Endocarditis

Infective Endocarditis. Infective Endocarditis. Prepared by : Abdullah Mosluh Abdullah Academic No. :426810123 Bader Nasser Al-Msaed. Definition . infection of the endocardial surface of the heart, which may include one or more heart valves, the mural endocardium, or a septal defect.

sidney
Download Presentation

Infective Endocarditis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Infective Endocarditis Infective Endocarditis Prepared by : Abdullah Mosluh Abdullah Academic No. :426810123 Bader Nasser Al-Msaed Infective ENDOCARDITIS

  2. Definition • infection of the endocardial surface of the heart, which may include one or more heart valves, the mural endocardium, or a septal defect. • Infectious endothelial lesions • Called Vegetation Primarily complication of congenital heart disease Infective ENDOCARDITIS

  3. pathogenesis Infective ENDOCARDITIS

  4. pathogens cause infective endocarditis Who is at high risk of infection by this organism ? Infective ENDOCARDITIS

  5. Clinical manifestation symptoms • Constitutional • Sweating • Anroxia • Weakness • Chill • Weight loss • Myalgia • Back pain Infective ENDOCARDITIS

  6. DUKE CRITERIA MAJOR CRITERIA include : • Microorganisms consistent with IE from persistently positive blood cultures defined as: • Two positive cultures of blood samples drawn >12 hours apart, or • All of 3 or a majority of 4 separate cultures of blood (with first and last sample drawn 1 hour apart) • Coxiella burnetii detected by at least one positive blood culture or antiphase I IgG antibody titer >1:800 • Evidence of endocardial involvement with positive echocardiogram defined as • Vegetation on valve • Abscess, or • new valvular regurgitation (worsening or changing of preexisting murmur not sufficient) Infective ENDOCARDITIS

  7. continue Minor criteria include: • Predisposing factor: known cardiac lesion, recreational drug injection • Fever >38°C • Evidence of embolism: arterial emboli, pulmonary infarcts, Janeway lesions, conjunctival hemorrhage • Immunological problems: glomerulonephritis, Osler's nodes roth spot rheumatoid factor • Positive blood culture (that doesn't meet a major criterion) or serologic evidence of infection with organism consistent with IE but not satisfying major criterion Infective ENDOCARDITIS

  8. The Roth Spot is a white-centered hemorrhage Infective ENDOCARDITIS

  9. Osler Nodules Skin janeway lesion Infective ENDOCARDITIS

  10. LABORATORY STUDIES & IMAGING • Multiple blood cultures • ESR& CRP↑ • Leukocytosis, anemia & hematuria • +ve rheumatoid factor • ECHO Infective ENDOCARDITIS

  11. TREATMENT • Acutely ill persons → empirical antibiotic therapy • Subacute disease → wait results of blood cultures • Bactericidal antibiotic → 4 to 8 weeks • IE ( viridans streptococci ) → monotherapy penicillin G for 4 weeks Infective ENDOCARDITIS

  12. Surgery will be indicated in the following conditions: • Unsuccessful medical treatment with persistant bacterimia • Fungal endocarditis • Valve annulus or myocardial abscess • Rupture of valve leaflet • Valvular insufficiency with acute or refractory heart failure • Recurrent serious embolic complications • Refractory prosthetic valve disease Infective ENDOCARDITIS

  13. High risk pt. for IE Should be received prophylactic antibiotics before & during all dental procedures as well as invasive procedure of resp. tract ,infected skin or muscle. PREVENTION • Prosthetic cardiac valves • Previous IE • Unrepaired cyanotic congenital heart disease • Valvular lesions in posttransplant pt. Oral amoxicillin 50 mg/ kg ( 30 – 60 min ) Clindamycin or azithromycin ( allergic to β – lactam) Infective ENDOCARDITIS

  14. THANK YOU THANK YOU Infective ENDOCARDITIS

More Related