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ETH Zürich Separation Technology

ETH Zürich Separation Technology. 03. Dec 2013. Chiral Column Technology New Generation of Cellulose and Amylose Columns. Smaller particle size (5µm) High loading capacity Pressure stable up to 300 bar Faster separation Save solvent Stable in NP, Polar Organic, SFC and RP conditions

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ETH Zürich Separation Technology

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  1. ETH Zürich Separation Technology 03. Dec 2013

  2. Chiral Column TechnologyNew Generation of Cellulose and Amylose Columns • Smaller particle size (5µm) • High loading capacity • Pressure stable up to 300 bar • Faster separation • Save solvent • Stable in NP, Polar Organic, SFC and RP conditions • pH stable 2-9 • Novel selectivity

  3. Chiral Column TechnologyLux Cellulose-2

  4. Chiral Column TechnologyLux Amylose-2

  5. Chiral Column TechnologyExample 1 Chiralpak AD, 5% EtOH/Heptane Reprosil Chiral NR, 10% EtOH/Heptane Peak A -

  6. Chiral Column TechnologyExample 1 Lux 2 Cellulose, 3% EtOH/Heptane Lux 2 Amylose, 20% EtOH/Heptane Peak A +

  7. Chiral Column TechnologyExample 2 Chiralpak AD, 5% EtOH/Heptane Reprosil Chiral NR, 3% EtOH/Heptane

  8. Chiral Column TechnologyExample 2 The devil is in the (D)ethyl Lux2 Cellulose, 5% EtOH/Heptane Lux 2 Amylose, 2% EtOH/Heptane

  9. Chiral Column TechnologyUsed Column for prep. Separation 2013

  10. Chiral Detection The CHIRALYSER is a high performance Optical Rotation Detector for monitoring Optically Active compounds in HPLC. Innovative flow cell design in multi path technology together with an optimized measuring wavelength performs outstanding sensitivity and excellent signal to noise ratio. The approved Faraday Compensation, superior to all other methods, enables the CHIRALYSER - MP to detect optical active molecules not only in analytical but also in preparative LC. Operation via touch screen or remote controlled by host computer adapts the CHIRALYSER to any chromatography system.

  11. Column Lifetime • dry solvents • < 0.01% water • clean samples • > 90% + no base line Peak in TLC • Pressure • < 30 bar • Chiralpak AD Nov/07 1700 runs • Chiralpak AD Nov/06 3200 runs • Reprosil Chiral NR Aug/08 2700 runs Cost per column ~25`000 CHF Cost per sample 10-20 CHF 250

  12. Doing now what patients need next

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