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Chapt 8 & 9: Genetics and chromosomes

Chapt 8 & 9: Genetics and chromosomes. Topics: What is genetics? What are chromosomes? Last review. ……. a nutshell. Basics- of life. Mendelian genetics. Mutations: Mendel and molecular. Meiosis, segregation. Mendelian segregation. Mutations- fine level. Mutation- gross level.

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Chapt 8 & 9: Genetics and chromosomes

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  1. Chapt 8 & 9: Genetics and chromosomes Topics: • What is genetics? • What are chromosomes? • Last review. ……. a nutshell

  2. Basics- of life

  3. Mendelian genetics

  4. Mutations: Mendel and molecular

  5. Meiosis, segregation

  6. Mendelian segregation

  7. Mutations- fine level

  8. Mutation- gross level

  9. [a] molecular basis for genetic disease

  10. Chemical basis of mutation, in life

  11. In lab “classical mutations” • First mutation “white” • UBX

  12. “Classical” mutations

  13. Another view of pathways

  14. [a] biochemical basis of mutation

  15. Genomics basis of mutation

  16. Mendel again

  17. More complicated -dosage -penetrance

  18. Gross level of mutation- chromosomal based

  19. Biotechnology- fingerprinting etc

  20. Mendel and alleles

  21. chromosomes

  22. Painting • False colors

  23. chromosomes

  24. In practice- microscopy

  25. Chromosome mapping- painting

  26. Euk redux of prok: “knock-out”- deletion

  27. More redux: transgenic

  28. Flies, plants

  29. Prok vs Euk genes

  30. Splicing, in a minute

  31. Low vs “High” euk: genes • 80kb genomic

  32. example • Blue= coding • Tan= non

  33. ‘real’ “BINF”

  34. histones Octomer: H2A, H2B, H3, H4 H1

  35. Molecular basis of speciation

  36. Summary- chromosome

  37. Gross mutations- genomic basis for “inborn errors of metabolism”

  38. Chromosome walking/mapping

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