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By Mostafa Abo Elsoud (National Research Center, Egypt)

Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation. By Mostafa Abo Elsoud (National Research Center, Egypt). Supervised by Marina L yashko Svetlana Aksenova. Laboratory of Radiation Biology (LRB), JINR, Russia.

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By Mostafa Abo Elsoud (National Research Center, Egypt)

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  1. Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation By MostafaAboElsoud (National Research Center, Egypt) Supervised by Marina Lyashko Svetlana Aksenova Laboratory of Radiation Biology (LRB), JINR, Russia.

  2. The SOS response in Escherichia coli bacteria is a set of inducible physiological reactions that help a cell to survive after the treatment with various DNA-damaging agents, such as ultraviolet, ionizing radiation and some chemicals. • More than 40 genes are induced in response to DNA damage as part of the SOS regulonin Escherichia coli. • SOS repair may result in SOS mutagenesis due to the inhibition of the proofreading activity of the epsilon subunit of DNA Pol III.

  3. Cyclobutane pyrimidinedimers (CPD) And pyrimidinepyrimidone photoproduct (6-4 PP) Lex A UV RecA Umuc, UmuD, DinI SOS gene box RecA* Mechanism of SOS repair system activation

  4. ssDNA+RecA+ATP Mechanism of SOS repair system RecA* DinI LexA UmuD UmuD’ . umuC umuD dinI . UmuD2 UmuDD’ UmuD’2 UmuC UmuD2C UmuD’2C UmuDD’C Pol V

  5. Thank you

  6. Thank you

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