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Zinc Fingers

Zinc Fingers. By Jeffrey Mah Biotechnology 2009-2010. Definition:. A type of small protein with 20-30 amino acids Bonded to a zinc ion Play essential roles in DNA recognition. Found in:. Thousands of other proteins Plants Animals BUT not bacteria . Function/Regulation:.

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Zinc Fingers

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  1. Zinc Fingers By Jeffrey Mah Biotechnology 2009-2010

  2. Definition: • A type of small protein with 20-30 amino acids • Bonded to a zinc ion • Play essential roles • in DNA recognition

  3. Found in: • Thousands of other proteins • Plants • Animals • BUT not bacteria

  4. Function/Regulation: • The expression of genes • Assembly of viruses • Reverse transcription • Nucleic acid recognition • Stabilizes and solidifies DNA and RNA

  5. Structure: • Main structure: • 1 tetrahedron • - 2 Cysteines • - 2 Histidines • - 1 zinc ion

  6. Structure: The other 15-25 amino acids all face more-or-less outwards, and can be used for various functional tasks

  7. Significance: • Tiny protein that helps with DNA related work • Researchers are currently trying to design artificial zinc fingers with different specificities

  8. Work Cited • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_2.html • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_3.html • http://upload.wikimedia.org/wikipedia/commons/7/79/Zinc_finger_DNA_complex.png

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