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Metabolism of Nutrients in Stomach and Intestine

Metabolism of Nutrients in Stomach and Intestine. Anusorn Cherdthong , PhD 137748 Applied Biochemistry in Nutritional Science Email: anusornc@kku.ac.th E-learning: http://ags.kku.ac.th/eLearning/137748. Introduction. Metabolism: Catabolism: large  small molecule and receiving ATP

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Metabolism of Nutrients in Stomach and Intestine

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  1. Metabolism of Nutrients in Stomach and Intestine AnusornCherdthong, PhD 137748 Applied Biochemistry in Nutritional Science Email: anusornc@kku.ac.th • E-learning: http://ags.kku.ac.th/eLearning/137748

  2. Introduction • Metabolism: • Catabolism: large  small molecule and receiving ATP • Anabolism: small large molecule and spend ATP, NADPH

  3. Metabolism in stomach • Carbohydrate: overview • Mouth: -amylase • Teeth • Esophagus • Stomach: no amylase • Small/large intestine: enzymes • Rectal: excretion

  4. Metabolism in stomach Wanapat et al. (2013)

  5. Metabolism in stomach • Carbohydrate: Rumen metabolism • poly mono saccharide: extracellular microbial enzyme: • Cellulose—cellobiose • Hemicellulose—cellobiose • Pectin—methanol and pectic acid • Mono saccharidepyruvate • Pyruvate---VFA, CH4 • C2, C3 and C4

  6. Metabolism in stomach • Carbohydrate: Rumen metabolism McDonald et al. (2011)

  7. Metabolism in stomach • VFV synthesis in rumen McDonald et al. (2011)

  8. Metabolism in stomach • Protein: overview in stomach • Gastrin hormone • HCl excretion: low pH (2.0) • Pepsinogen excretion: proenzyme for peptide degrade

  9. Metabolism in stomach • Protein: Rumen • Proteiolytic microorganism • Bacteria • Protozoa • Fungi McDonald et al. (2011)

  10. Metabolism in stomach • Lipid: overview in stomach • No digest in non ruminant stomach • Ruminant act by rumen microbes by: • Hydrolysis • Hydrogenation • Isomerization

  11. Metabolism in intestine • Carbohydrate: • Require enzyme for pancreases: • -amylase • -glucosidase • Maltase • -dextrinase

  12. Metabolism in intestine • Protein metabolism in small intestine: Modified from Cunningham (1992)

  13. Metabolism in intestine • Protein metabolism in small intestine: Modified from Cunningham (1992)

  14. Metabolism in intestine • Lipid metabolism in small intestine: • Triacyl glycerol • Required bile salt as emulsifier • Excreatecholecystokinin and secretin • Formulation of mixed micelle for transfer and absorption • Bile recycle when reaction finished • Required pancreatic lipase

  15. Metabolism in intestine • Lipid: Absorption • Chylomicron: lipoprotein • Via lymph system---blood---tissue • Metabolism in liver, storage Nelson and Cox (2000)

  16. Metabolism in large intestine: • A few metabolism in this part • Digest some cellulose by-pass • Work by bacteria • Re-absorption of nutrients • Essential for equine: fiber digestion

  17. 1 2 3 Conclusion Metabolism of nutrient in stomach Metabolism of nutrient in intestine Utilization of nutrient in different animal al species

  18. Thank you!

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