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DISCIPLINE Nutrition Psychology Biology Ag Econ Food Science Animal Science

Ingestive Behavior Research Center. APPROACH Genetic Molecular Cellular Organ System Organism Behavior Policy. DETERMINANTS Culture Cognitive Sensory Physical Endocrine Metabolic Neural Thermogenic. DISCIPLINE Nutrition Psychology Biology

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DISCIPLINE Nutrition Psychology Biology Ag Econ Food Science Animal Science

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  1. Ingestive Behavior Research Center APPROACH Genetic Molecular Cellular Organ System Organism Behavior Policy DETERMINANTS Culture Cognitive Sensory Physical Endocrine Metabolic Neural Thermogenic DISCIPLINE Nutrition Psychology Biology Ag Econ Food Science Animal Science Nursing Health Kinesiology INGESTIVE BEHAVIOR

  2. Current IBRC Research Foci • Metabolic and Neurohormonal Controls of Feeding Behavior • Lifespan Influences on the Regulation of Ingestion and Body Weight • The Nature and Function of Gastrointestinal Stimuli • The Role of Experience, Cognition, and Sensory Stimuli in Disorders of Intake Regulation

  3. Factors Contributing to LessThan Predicted Weight Gain • Strong Appetitive Control • Elevated Energy Expenditure • Energy Loss

  4. EnergyIntake Week 4, 8, 17, 21 Protocol Compliance Week 1, 10, 14, 23 Hollis J & Mattes R. Br J Nutr 2007;98:651-656.

  5. Hoad CL et al., J. Nutr 2004;134:2293-2300

  6. Leptin Insulin Amylin NPY CRH UCN UCNII Galanin Neurotensin CART Oxytocin Alpha-MSH CCK Corticosterone Serotonin Dopamine MCH Orexins Ghrelin GLP-1 GLP-2 AgRP Beacon Cannabinoids Neuroendocrine Factors inFeeding Regulation • TNF-alpha • Beta-Endorphin • Dynorphin • BDNF • PYY • IL-6 • IL-1 • IL-1RA • Norepinephrine • Amino Acids • PRL-RL • GAL-LP

  7. Factors Contributing to LessThan Predicted Weight Gain • Strong Appetitive Control • Elevated Energy Expenditure • Energy Loss

  8. Protocol Energy Expenditure RMR & TEF PA TEE Week 4, 8,14, 21 (3 Days) Week 8, 21 Week 1, 8, 14, 21 Hollis J & Mattes R. Br J Nutr 2007;98:651-656.

  9. Factors Contributing to LessThan Predicted Weight Gain • Strong Appetitive Control • Elevated Energy Expenditure • Energy Loss

  10. Ellis et al., AJCN 2004;80:604.

  11. Executive Committee: Director: Terry Davidson (Psychological Sciences) Associate Director: Richard Mattes (Foods and Nutrition) Members: • Wayne Campbell (Foods and Nutrition) • Susan Chen (Agricultural Economics) • Shawn Donkin (Animal Sciences) • Edward Fox, (Psychological Sciences) • Terry Powley (Psychological Sciences) • Susan Swithers (Psychological Sciences)

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